| http://purl.uniprot.org/citations/15331325 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15331325 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously showed that, in the context of thymic epithelial cells, thymocyte migration is partially controlled by extracellular matrix (ECM)-mediated interactions. Herein we evaluated whether these interactions could be involved in cell migration related events in the context of non-epithelial cells of the thymic microenvironment, the phagocytic cells of the thymic reticulum (PTR). We first showed, by immunocytochemistry, cytofluorometry, and RT-PCR, that PTR produce ECM components, including fibronectin and laminin, and express the corresponding integrin-type receptors, VLA-4, VLA-5, and VLA-6. Thymocytes adhere onto PTR monolayers, with immature CD4(+)CD8(+) cells being predominant. Importantly, such an adhesion is partially mediated by ECM ligands and receptors, since it was impaired by anti-ECM or anti-ECM receptor antibodies. Conjointly, our data reveal that the ECM-dependence for thymocyte adhesion onto the thymic microenvironment is not restricted to the epithelial cells, being also seen when they encounter non-epithelial phagocytic cells."xsd:string |
| http://purl.uniprot.org/citations/15331325 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellimm.2004.06.002"xsd:string |
| http://purl.uniprot.org/citations/15331325 | http://purl.uniprot.org/core/author | "Savino W."xsd:string |
| http://purl.uniprot.org/citations/15331325 | http://purl.uniprot.org/core/author | "Brito J.M."xsd:string |
| http://purl.uniprot.org/citations/15331325 | http://purl.uniprot.org/core/author | "Lannes-Vieira J."xsd:string |
| http://purl.uniprot.org/citations/15331325 | http://purl.uniprot.org/core/author | "Villa-Verde D.M."xsd:string |
| http://purl.uniprot.org/citations/15331325 | http://purl.uniprot.org/core/author | "Farias-De-Oliveira D.A."xsd:string |
| http://purl.uniprot.org/citations/15331325 | http://purl.uniprot.org/core/author | "Ayres-Martins S."xsd:string |
| http://purl.uniprot.org/citations/15331325 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15331325 | http://purl.uniprot.org/core/name | "Cell Immunol"xsd:string |
| http://purl.uniprot.org/citations/15331325 | http://purl.uniprot.org/core/pages | "21-30"xsd:string |
| http://purl.uniprot.org/citations/15331325 | http://purl.uniprot.org/core/title | "Phagocytic cells of the thymic reticulum interact with thymocytes via extracellular matrix ligands and receptors."xsd:string |
| http://purl.uniprot.org/citations/15331325 | http://purl.uniprot.org/core/volume | "229"xsd:string |
| http://purl.uniprot.org/citations/15331325 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15331325 |
| http://purl.uniprot.org/citations/15331325 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15331325 |
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