| http://purl.uniprot.org/citations/15331764 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15331764 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15331764 | http://www.w3.org/2000/01/rdf-schema#comment | "The structural maintenance of chromosomes (SMC) family of proteins play key roles in the organization, packaging, and repair of chromosomes. Cohesin (Smc1+3) holds replicated sister chromatids together until mitosis, condensin (Smc2+4) acts in chromosome condensation, and Smc5+6 performs currently enigmatic roles in DNA repair and chromatin structure. The SMC heterodimers must associate with non-SMC subunits to perform their functions. Using both biochemical and genetic methods, we have isolated a novel subunit of the Smc5+6 complex, Nse3. Nse3 is an essential nuclear protein that is required for normal mitotic chromosome segregation and cellular resistance to a number of genotoxic agents. Epistasis with Rhp51 (Rad51) suggests that like Smc5+6, Nse3 functions in the homologous recombination based repair of DNA damage. We previously identified two non-SMC subunits of Smc5+6 called Nse1 and Nse2. Analysis of nse1-1, nse2-1, and nse3-1 mutants demonstrates that they are crucial for meiosis. The Nse1 mutant displays meiotic DNA segregation and homologous recombination defects. Spore viability is reduced by nse2-1 and nse3-1, without affecting interhomolog recombination. Finally, genetic interactions shared by the nse mutants suggest that the Smc5+6 complex is important for replication fork stability."xsd:string |
| http://purl.uniprot.org/citations/15331764 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e04-05-0436"xsd:string |
| http://purl.uniprot.org/citations/15331764 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e04-05-0436"xsd:string |
| http://purl.uniprot.org/citations/15331764 | http://purl.uniprot.org/core/author | "Yates J.R. III"xsd:string |
| http://purl.uniprot.org/citations/15331764 | http://purl.uniprot.org/core/author | "Yates J.R. III"xsd:string |
| http://purl.uniprot.org/citations/15331764 | http://purl.uniprot.org/core/author | "McDonald W.H."xsd:string |
| http://purl.uniprot.org/citations/15331764 | http://purl.uniprot.org/core/author | "McDonald W.H."xsd:string |
| http://purl.uniprot.org/citations/15331764 | http://purl.uniprot.org/core/author | "Boddy M.N."xsd:string |
| http://purl.uniprot.org/citations/15331764 | http://purl.uniprot.org/core/author | "Boddy M.N."xsd:string |
| http://purl.uniprot.org/citations/15331764 | http://purl.uniprot.org/core/author | "Pavlova Y."xsd:string |
| http://purl.uniprot.org/citations/15331764 | http://purl.uniprot.org/core/author | "Pavlova Y."xsd:string |
| http://purl.uniprot.org/citations/15331764 | http://purl.uniprot.org/core/author | "Pebernard S."xsd:string |
| http://purl.uniprot.org/citations/15331764 | http://purl.uniprot.org/core/author | "Pebernard S."xsd:string |
| http://purl.uniprot.org/citations/15331764 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15331764 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15331764 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/15331764 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/15331764 | http://purl.uniprot.org/core/pages | "4866-4876"xsd:string |
| http://purl.uniprot.org/citations/15331764 | http://purl.uniprot.org/core/pages | "4866-4876"xsd:string |
| http://purl.uniprot.org/citations/15331764 | http://purl.uniprot.org/core/title | "Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis."xsd:string |
| http://purl.uniprot.org/citations/15331764 | http://purl.uniprot.org/core/title | "Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis."xsd:string |
| http://purl.uniprot.org/citations/15331764 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/15331764 | http://purl.uniprot.org/core/volume | "15"xsd:string |