| http://purl.uniprot.org/citations/15333704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15333704 | http://www.w3.org/2000/01/rdf-schema#comment | "The response of plasma lipids to dietary cholesterol and fat varies among individuals. Variations in genes involved in cholesterol metabolism can be important in these interindividual differences. The rate-limiting enzyme in the conversion of cholesterol into bile acids is cholesterol 7alpha-hydroxylase (CYP7A1). We investigated the effect of the A278-C promoter polymorphism in the CYP7A1 gene on responses of plasma lipids to an increased intake in dietary cholesterol (742 +/- 114 mg/d), cafestol (57 +/-6 mg/d), saturated fat [change of 8-9 energy percent/d (en%/d)] and trans fat (change of 10-11 en%/d) in 496 normolipidemic subjects. These responses were measured in 26 previously published dietary trials. After adjustment for the apolipoprotein E genotype effect, AA-subjects consuming a cholesterol-rich diet had a smaller increase in plasma HDL cholesterol than CC-subjects (0.00 +/-0.02 vs. 0.17 +/-0.04 mmol/L; P < 0.001). Upon intake of cafestol, AA-subjects had a smaller increase in plasma total cholesterol than CC-subjects (0.69 +/-0.10 vs. 1.01 +/-0.10 mmol/L; P = 0.028). No effects of the polymorphism were found in the saturated and trans fat interventions. In conclusion, the CYP7A1 polymorphism has a small but significant effect on the increase in plasma HDL cholesterol and plasma total cholesterol after an increased intake of dietary cholesterol and cafestol, respectively."xsd:string |
| http://purl.uniprot.org/citations/15333704 | http://purl.org/dc/terms/identifier | "doi:10.1093/jn/134.9.2200"xsd:string |
| http://purl.uniprot.org/citations/15333704 | http://purl.uniprot.org/core/author | "Katan M.B."xsd:string |
| http://purl.uniprot.org/citations/15333704 | http://purl.uniprot.org/core/author | "Princen H.M."xsd:string |
| http://purl.uniprot.org/citations/15333704 | http://purl.uniprot.org/core/author | "Weggemans R.M."xsd:string |
| http://purl.uniprot.org/citations/15333704 | http://purl.uniprot.org/core/author | "Zock P.L."xsd:string |
| http://purl.uniprot.org/citations/15333704 | http://purl.uniprot.org/core/author | "Schouten E.G."xsd:string |
| http://purl.uniprot.org/citations/15333704 | http://purl.uniprot.org/core/author | "Hofman M.K."xsd:string |
| http://purl.uniprot.org/citations/15333704 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15333704 | http://purl.uniprot.org/core/name | "J Nutr"xsd:string |
| http://purl.uniprot.org/citations/15333704 | http://purl.uniprot.org/core/pages | "2200-2204"xsd:string |
| http://purl.uniprot.org/citations/15333704 | http://purl.uniprot.org/core/title | "CYP7A1 A-278C polymorphism affects the response of plasma lipids after dietary cholesterol or cafestol interventions in humans."xsd:string |
| http://purl.uniprot.org/citations/15333704 | http://purl.uniprot.org/core/volume | "134"xsd:string |
| http://purl.uniprot.org/citations/15333704 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15333704 |
| http://purl.uniprot.org/citations/15333704 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15333704 |
| http://purl.uniprot.org/uniprot/#_P22680-mappedCitation-15333704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15333704 |
| http://purl.uniprot.org/uniprot/P22680 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15333704 |