| http://purl.uniprot.org/citations/15337530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15337530 | http://www.w3.org/2000/01/rdf-schema#comment | "We have characterized the role of Drosophila PI3K and AKT in ERK pathway activation involving insulin-induced proliferation using Drosophila Schneider cells. After insulin treatment, dPI3K and dAKT activities were both increased along with activation of the dERK pathway components dMEK and dERK. The insulin-induced activations of dERK and dAKT were blocked by LY294002, dPTEN, and by an AKT inhibitor, indicating involvement of dPI3K and dAKT in the insulin-induced dERK and dAKT activations. Proliferation and the G1 to S phase cell cycle progression due to insulin were also blocked by PI3K and AKT inhibitors, indicating that the Drosophila PI3K-AKT pathway involves insulin-mediated cell proliferation. The insulin-stimulated size increase was blocked by both LY294002 and AKT inhibitor, not by U0126, indicating that insulin-mediated size control by dPI3K and dAKT occurs independently of the ERK pathway. This study indicates that dPI3K and dAKT are involved in insulin-induced ERK pathway activation leading to proliferation in Drosophila Schneider cells."xsd:string |
| http://purl.uniprot.org/citations/15337530 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2004.04.004"xsd:string |
| http://purl.uniprot.org/citations/15337530 | http://purl.uniprot.org/core/author | "Lee S.J."xsd:string |
| http://purl.uniprot.org/citations/15337530 | http://purl.uniprot.org/core/author | "Kim K.S."xsd:string |
| http://purl.uniprot.org/citations/15337530 | http://purl.uniprot.org/core/author | "Lee K.H."xsd:string |
| http://purl.uniprot.org/citations/15337530 | http://purl.uniprot.org/core/author | "Kim S.E."xsd:string |
| http://purl.uniprot.org/citations/15337530 | http://purl.uniprot.org/core/author | "Choi K.Y."xsd:string |
| http://purl.uniprot.org/citations/15337530 | http://purl.uniprot.org/core/author | "Cho J.Y."xsd:string |
| http://purl.uniprot.org/citations/15337530 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15337530 | http://purl.uniprot.org/core/name | "Cell Signal"xsd:string |
| http://purl.uniprot.org/citations/15337530 | http://purl.uniprot.org/core/pages | "1309-1317"xsd:string |
| http://purl.uniprot.org/citations/15337530 | http://purl.uniprot.org/core/title | "Drosophila PI3 kinase and Akt involved in insulin-stimulated proliferation and ERK pathway activation in Schneider cells."xsd:string |
| http://purl.uniprot.org/citations/15337530 | http://purl.uniprot.org/core/volume | "16"xsd:string |
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