| http://purl.uniprot.org/citations/15340007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15340007 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15340007 | http://www.w3.org/2000/01/rdf-schema#comment | "Outer dense fibre protein 2 (ODF2) is a major protein of sperm tail outer dense fibres which are prominent sperm tail-specific cytoskeletal structures. Moreover, ODF2 was also identified as a widespread component of the centrosomal scaffold and was found to associate preferentially with the appendages of the mother centriole [Nakagawa, Y., Yamane, Y., Okanoue, T., Tsukita, S. and Tsukita, S. (2001) Mol. Biol. Cell 12, 1687-1697]. Secondary structure predictions indicated ODF2 as an overall coiled-coil protein with a putative fibre forming capacity. To investigate its potential functions in generating the centrosomal scaffold and in microtubule nucleation we asked whether ODF2 is able to form a fibrillar structure by self-association in vivo and if it interacts with microtubules. By cytological investigation of transfected mammalian cells expressing ODF2-GFP fusion proteins and in vitro coprecipitation assays we could demonstrate that ODF2 is a self-interacting protein that forms a fibrillar structure partially linked to the microtubule network. Microtubule cosedimentation and coprecipitation assays indicated ODF2 as a microtubule-associated protein. However, we could not demonstrate a direct interaction of ODF2 with tubulin, suggesting that binding of endogenous ODF2 to the axonemal as well as to centrosomal microtubules may be mediated by, as yet, unknown proteins."xsd:string |
| http://purl.uniprot.org/citations/15340007 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.01303"xsd:string |
| http://purl.uniprot.org/citations/15340007 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.01303"xsd:string |
| http://purl.uniprot.org/citations/15340007 | http://purl.uniprot.org/core/author | "Hoyer-Fender S."xsd:string |
| http://purl.uniprot.org/citations/15340007 | http://purl.uniprot.org/core/author | "Hoyer-Fender S."xsd:string |
| http://purl.uniprot.org/citations/15340007 | http://purl.uniprot.org/core/author | "Czirr E."xsd:string |
| http://purl.uniprot.org/citations/15340007 | http://purl.uniprot.org/core/author | "Czirr E."xsd:string |
| http://purl.uniprot.org/citations/15340007 | http://purl.uniprot.org/core/author | "Hollemann T."xsd:string |
| http://purl.uniprot.org/citations/15340007 | http://purl.uniprot.org/core/author | "Hollemann T."xsd:string |
| http://purl.uniprot.org/citations/15340007 | http://purl.uniprot.org/core/author | "Monnich M."xsd:string |
| http://purl.uniprot.org/citations/15340007 | http://purl.uniprot.org/core/author | "Monnich M."xsd:string |
| http://purl.uniprot.org/citations/15340007 | http://purl.uniprot.org/core/author | "Donkor F.F."xsd:string |
| http://purl.uniprot.org/citations/15340007 | http://purl.uniprot.org/core/author | "Donkor F.F."xsd:string |
| http://purl.uniprot.org/citations/15340007 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15340007 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15340007 | http://purl.uniprot.org/core/name | "J. Cell Sci."xsd:string |
| http://purl.uniprot.org/citations/15340007 | http://purl.uniprot.org/core/name | "J. Cell Sci."xsd:string |
| http://purl.uniprot.org/citations/15340007 | http://purl.uniprot.org/core/pages | "4643-4651"xsd:string |
| http://purl.uniprot.org/citations/15340007 | http://purl.uniprot.org/core/pages | "4643-4651"xsd:string |
| http://purl.uniprot.org/citations/15340007 | http://purl.uniprot.org/core/title | "Outer dense fibre protein 2 (ODF2) is a self-interacting centrosomal protein with affinity for microtubules."xsd:string |
| http://purl.uniprot.org/citations/15340007 | http://purl.uniprot.org/core/title | "Outer dense fibre protein 2 (ODF2) is a self-interacting centrosomal protein with affinity for microtubules."xsd:string |
| http://purl.uniprot.org/citations/15340007 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/15340007 | http://purl.uniprot.org/core/volume | "117"xsd:string |