| http://purl.uniprot.org/citations/15340075 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15340075 | http://www.w3.org/2000/01/rdf-schema#comment | "Germ line DNA directs the development of the next generation and, as such, is profoundly different from somatic cell DNA. Spermatogenic cells obtained from young adult lacI transgenic mice display a lower spontaneous mutant frequency and greater in vitro base excision repair activity than somatic cells and tissues obtained from the same mice. However, spermatogenic cells from old lacI mice display a 10-fold higher mutant frequency. This increased spontaneous mutant frequency occurs coincidentally with decreased in vitro base excision repair activity for germ cell and testicular extracts that in turn corresponds to a decreased abundance of AP endonuclease. To directly test whether a genetic diminution of AP endonuclease results in increased spontaneous mutant frequencies in spermatogenic cell types, AP endonuclease heterozygous (Apex(+/-)) knockout mice were crossed with lacI transgenic mice. Spontaneous mutant frequencies were significantly elevated (approximately twofold) for liver and spleen obtained from 3-month-old Apex(+/-) lacI(+) mice compared to frequencies from Apex(+/+) lacI(+) littermates and were additionally elevated for somatic tissues from 9-month-old mice. Spermatogenic cells from 9-month-old Apex(+/-) lacI(+) mice were significantly elevated twofold compared to levels for 9-month-old Apex(+/+) lacI(+) control mice. These data indicate that diminution of AP endonuclease has a significant effect on spontaneous mutagenesis in somatic and germ line cells."xsd:string |
| http://purl.uniprot.org/citations/15340075 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.24.18.8145-8153.2004"xsd:string |
| http://purl.uniprot.org/citations/15340075 | http://purl.uniprot.org/core/author | "McCarrey J.R."xsd:string |
| http://purl.uniprot.org/citations/15340075 | http://purl.uniprot.org/core/author | "Chen D.J."xsd:string |
| http://purl.uniprot.org/citations/15340075 | http://purl.uniprot.org/core/author | "Walter C.A."xsd:string |
| http://purl.uniprot.org/citations/15340075 | http://purl.uniprot.org/core/author | "Reddick R."xsd:string |
| http://purl.uniprot.org/citations/15340075 | http://purl.uniprot.org/core/author | "Herbert D.C."xsd:string |
| http://purl.uniprot.org/citations/15340075 | http://purl.uniprot.org/core/author | "McMahan C.A."xsd:string |
| http://purl.uniprot.org/citations/15340075 | http://purl.uniprot.org/core/author | "Huamani J."xsd:string |
| http://purl.uniprot.org/citations/15340075 | http://purl.uniprot.org/core/author | "MacInnes M.I."xsd:string |
| http://purl.uniprot.org/citations/15340075 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15340075 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/15340075 | http://purl.uniprot.org/core/pages | "8145-8153"xsd:string |
| http://purl.uniprot.org/citations/15340075 | http://purl.uniprot.org/core/title | "Spontaneous mutagenesis is enhanced in Apex heterozygous mice."xsd:string |
| http://purl.uniprot.org/citations/15340075 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/15340075 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15340075 |
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