| http://purl.uniprot.org/citations/15341589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15341589 | http://www.w3.org/2000/01/rdf-schema#comment | "The anti-apoptotic proteins Bcl-w and Bcl-2 and the pro-apoptotic protein Bax may mediate cell death or survival via regulation of the mitochondria including second mitochondria-derived activator of caspase (Smac)/direct inhibitor of apoptosis protein (IAP)-binding protein with low pI (DIABLO) release. This study aimed to explore alterations in Bcl-w, Bcl-2, and Bax and the relationship between these proteins and Smac/DIABLO by means of in situ hybridization, immunohistochemical (IHC) staining, and Western blots after low- and high-intensity photothrombotic ring stroke. At 4 h after low-intensity irradiation, we found widespread bcl-w overexpression on both the mRNA and protein levels in the bilateral cortex except the ring lesion region and in subcortical regions. A prolonged elevation of Bcl-2 with relatively unchanged Bax in the mitochondrial fraction was demonstrated from 4 to 72 h. These upregulated anti-apoptotic proteins combined with little Smac/DIABLO release might be associated with increased cell survival and thereby remarkable morphological recovery after low-intensity irradiation. After high-intensity irradiation, we observed decreased bcl-w and bcl-2 mRNA with increased Bcl-2 protein in the cytosolic fraction, whereas the Bax protein remained in scattered ischaemic cells in the ring lesion and the region at risk that corresponded with release of Smac/DIABLO from mitochondria to the cytosol at 1-24 h. These changes might be related to the massive cell death observed after high-intensity irradiation. Taken together, the balance and the location of anti-apoptotic proteins vs. pro-apoptotic proteins could be associated with the translocation of Smac/DIABLO from the mitochondria to the cytosol and therefore closely related to cell death or survival after focal cerebral ischaemia."xsd:string |
| http://purl.uniprot.org/citations/15341589 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1460-9568.2004.03554.x"xsd:string |
| http://purl.uniprot.org/citations/15341589 | http://purl.uniprot.org/core/author | "Olsson T."xsd:string |
| http://purl.uniprot.org/citations/15341589 | http://purl.uniprot.org/core/author | "Hu X.L."xsd:string |
| http://purl.uniprot.org/citations/15341589 | http://purl.uniprot.org/core/author | "Brannstrom T."xsd:string |
| http://purl.uniprot.org/citations/15341589 | http://purl.uniprot.org/core/author | "Wester P."xsd:string |
| http://purl.uniprot.org/citations/15341589 | http://purl.uniprot.org/core/author | "Johansson I.M."xsd:string |
| http://purl.uniprot.org/citations/15341589 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15341589 | http://purl.uniprot.org/core/name | "Eur J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/15341589 | http://purl.uniprot.org/core/pages | "1177-1188"xsd:string |
| http://purl.uniprot.org/citations/15341589 | http://purl.uniprot.org/core/title | "Dynamic changes of the anti- and pro-apoptotic proteins Bcl-w, Bcl-2, and Bax with Smac/Diablo mitochondrial release after photothrombotic ring stroke in rats."xsd:string |
| http://purl.uniprot.org/citations/15341589 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/15341589 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15341589 |
| http://purl.uniprot.org/citations/15341589 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15341589 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZR69-mappedCitation-15341589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15341589 |
| http://purl.uniprot.org/uniprot/#_A6J143-mappedCitation-15341589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15341589 |
| http://purl.uniprot.org/uniprot/#_A6J145-mappedCitation-15341589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15341589 |
| http://purl.uniprot.org/uniprot/#_A0A8I6AJ02-mappedCitation-15341589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15341589 |
| http://purl.uniprot.org/uniprot/#_A0A8I6A7T3-mappedCitation-15341589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15341589 |
| http://purl.uniprot.org/uniprot/#_A6JB34-mappedCitation-15341589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15341589 |
| http://purl.uniprot.org/uniprot/#_F7F5S4-mappedCitation-15341589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15341589 |
| http://purl.uniprot.org/uniprot/#_P49950-mappedCitation-15341589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15341589 |
| http://purl.uniprot.org/uniprot/#_Q63690-mappedCitation-15341589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15341589 |
| http://purl.uniprot.org/uniprot/#_G3V8T9-mappedCitation-15341589 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15341589 |