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http://purl.uniprot.org/citations/15341727http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15341727http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15341727http://www.w3.org/2000/01/rdf-schema#comment"GlvA, a 6-phospho-alpha-glucosidase from Bacillus subtilis, catalyzes the hydrolysis of maltose-6'-phosphate and belongs to glycoside hydrolase family GH4. GH4 enzymes are unique in their requirement for NAD(H) and a divalent metal for activity. We have determined the crystal structure of GlvA in complex with its ligands to 2.05 A resolution. Analyses of the active site architecture, in conjunction with mechanistic studies and precedent from the nucleotide diphosphate hexose dehydratases and other systems, suggest a novel mechanism of glycoside hydrolysis by GlvA that involves both the NAD(H) and the metal."xsd:string
http://purl.uniprot.org/citations/15341727http://purl.org/dc/terms/identifier"doi:10.1016/j.str.2004.06.020"xsd:string
http://purl.uniprot.org/citations/15341727http://purl.org/dc/terms/identifier"doi:10.1016/j.str.2004.06.020"xsd:string
http://purl.uniprot.org/citations/15341727http://purl.uniprot.org/core/author"Anderson W.F."xsd:string
http://purl.uniprot.org/citations/15341727http://purl.uniprot.org/core/author"Anderson W.F."xsd:string
http://purl.uniprot.org/citations/15341727http://purl.uniprot.org/core/author"Davies G.J."xsd:string
http://purl.uniprot.org/citations/15341727http://purl.uniprot.org/core/author"Davies G.J."xsd:string
http://purl.uniprot.org/citations/15341727http://purl.uniprot.org/core/author"Rajan S.S."xsd:string
http://purl.uniprot.org/citations/15341727http://purl.uniprot.org/core/author"Rajan S.S."xsd:string
http://purl.uniprot.org/citations/15341727http://purl.uniprot.org/core/author"Thompson J."xsd:string
http://purl.uniprot.org/citations/15341727http://purl.uniprot.org/core/author"Thompson J."xsd:string
http://purl.uniprot.org/citations/15341727http://purl.uniprot.org/core/author"Yang X."xsd:string
http://purl.uniprot.org/citations/15341727http://purl.uniprot.org/core/author"Yang X."xsd:string
http://purl.uniprot.org/citations/15341727http://purl.uniprot.org/core/author"Varrot A."xsd:string
http://purl.uniprot.org/citations/15341727http://purl.uniprot.org/core/author"Varrot A."xsd:string
http://purl.uniprot.org/citations/15341727http://purl.uniprot.org/core/author"Withers S.G."xsd:string
http://purl.uniprot.org/citations/15341727http://purl.uniprot.org/core/author"Withers S.G."xsd:string
http://purl.uniprot.org/citations/15341727http://purl.uniprot.org/core/author"Yip V.L.Y."xsd:string
http://purl.uniprot.org/citations/15341727http://purl.uniprot.org/core/author"Yip V.L.Y."xsd:string
http://purl.uniprot.org/citations/15341727http://purl.uniprot.org/core/author"Collart F."xsd:string
http://purl.uniprot.org/citations/15341727http://purl.uniprot.org/core/author"Collart F."xsd:string
http://purl.uniprot.org/citations/15341727http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15341727http://purl.uniprot.org/core/date"2004"xsd:gYear