| http://purl.uniprot.org/citations/15343265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15343265 | http://www.w3.org/2000/01/rdf-schema#comment | "This study further defines genetic susceptibility to JIA in the region centromeric to HLA-DRB1. DNA from 234 Finnish JIA nuclear families and 639 elderly Finnish control individuals was genotyped for five functional SNPs within the TAP2 and TAP1 loci ( approximately 200 kb centromeric of HLA-DRB1). Subsets of the controls (186) and patients (145) that had been previously typed for HLA-DRB1 were also genotyped by sequence for the HLA-DPB1 locus. Case/control and transmission disequilibrium test (TDT) methods revealed an association with the DPB1(*)030101 allele for JIA (OR 2.3, 95% CI 1.5-3.5). Notably, a detailed haplotypic analysis of the TAP2/TAP1 loci and their interaction with the HLA-DPB1(*)030101 and DRB1(*)08 and (*)11 alleles showed a variety of over-represented and under-represented TAP2/TAP1 haplotypes not evident in the single marker analysis. The strongest effect was observed in the polyarticular RF negative JIA subgroup for the 2-2-1-2-1 TAP2/TAP1 haplotype (TAP2B and TAP1A alleles) which showed an independent effect from both DRB1(*)08 and (*)11 (P<0.000003) and DPB1(*)030101 (P=0.02). We have provided evidence that the extended haplotypes (including HLA-DRB1, TAP2/TAP1, and HLA-DPB1) of pauciarticular and polyarticular RF negative disease are distinct. This observation may have implications for functional etiological differences between the pauciarticular and polyarticular JIA patients."xsd:string |
| http://purl.uniprot.org/citations/15343265 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.gene.6364129"xsd:string |
| http://purl.uniprot.org/citations/15343265 | http://purl.uniprot.org/core/author | "Tuomilehto J."xsd:string |
| http://purl.uniprot.org/citations/15343265 | http://purl.uniprot.org/core/author | "Seldin M.F."xsd:string |
| http://purl.uniprot.org/citations/15343265 | http://purl.uniprot.org/core/author | "Savolainen A."xsd:string |
| http://purl.uniprot.org/citations/15343265 | http://purl.uniprot.org/core/author | "Tuomilehto-Wolf E."xsd:string |
| http://purl.uniprot.org/citations/15343265 | http://purl.uniprot.org/core/author | "Runstadler J.A."xsd:string |
| http://purl.uniprot.org/citations/15343265 | http://purl.uniprot.org/core/author | "Aho K."xsd:string |
| http://purl.uniprot.org/citations/15343265 | http://purl.uniprot.org/core/author | "Leirisalo-Repo M."xsd:string |
| http://purl.uniprot.org/citations/15343265 | http://purl.uniprot.org/core/author | "Saila H."xsd:string |
| http://purl.uniprot.org/citations/15343265 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15343265 | http://purl.uniprot.org/core/name | "Genes Immun"xsd:string |
| http://purl.uniprot.org/citations/15343265 | http://purl.uniprot.org/core/pages | "562-571"xsd:string |
| http://purl.uniprot.org/citations/15343265 | http://purl.uniprot.org/core/title | "HLA-DRB1, TAP2/TAP1, and HLA-DPB1 haplotypes in Finnish juvenile idiopathic arthritis: more complexity within the MHC."xsd:string |
| http://purl.uniprot.org/citations/15343265 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/15343265 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15343265 |
| http://purl.uniprot.org/citations/15343265 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15343265 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-15343265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15343265 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-15343265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15343265 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-15343265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15343265 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C545-mappedCitation-15343265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15343265 |
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| http://purl.uniprot.org/uniprot/#_A0A0A7C554-mappedCitation-15343265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15343265 |
| http://purl.uniprot.org/uniprot/#_A0A0A0WDZ3-mappedCitation-15343265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15343265 |