| http://purl.uniprot.org/citations/15345745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15345745 | http://www.w3.org/2000/01/rdf-schema#comment | "CRH-binding protein (CRH-BP) regulates activation of the hypothalamic-pituitary-adrenal (HPA) axis by binding and inhibiting CRH. We investigated for the first time transcriptional regulation of the human CRH-BP promoter using transient transfections. Estrogen receptors (ERs) contributed to ligand-independent constitutive activation of the promoter, whereas in the presence of estradiol ERalpha induced and ERbeta repressed promoter activity in a dose-dependent manner. TNFalpha inhibited promoter induction by ERalpha in the absence and presence of estradiol. Three ERE half-sites in the CRH-BP promoter bound ERalpha and ERbeta in an EMSA, and disruption of ERE half-sites by site-directed mutagenesis abolished ligand-independent induction by ERalpha and ERbeta and promoter enhancement by estradiol-activated ERalpha. Repression by estradiol/ERbeta was unaffected by disruption of ERE half-sites, activating protein 1, cAMP response element, GATA, or nuclear factor kappaB sites, and reversed to promoter induction by estrogen antagonists, tamoxifen and ICI 182,780, suggesting corepressor involvement. In hypothalamic GT1-7 cells, Western blotting demonstrated rapid induction of endogenous CRH-BP expression by estradiol-bound ER, which was inhibited by TNFalpha. We propose a model in which ERs maintain basal CRH-BP expression in pituitary and neurosecretory cells, whereas in the presence of ERalpha estrogen enhances CRH-BP transcription, causing down-regulation of the HPA axis, and nuclear factor kappaB-activating cytokines activate the HPA axis by inhibiting ERalpha."xsd:string |
| http://purl.uniprot.org/citations/15345745 | http://purl.org/dc/terms/identifier | "doi:10.1210/me.2003-0446"xsd:string |
| http://purl.uniprot.org/citations/15345745 | http://purl.uniprot.org/core/author | "Behl C."xsd:string |
| http://purl.uniprot.org/citations/15345745 | http://purl.uniprot.org/core/author | "Zomer A.W."xsd:string |
| http://purl.uniprot.org/citations/15345745 | http://purl.uniprot.org/core/author | "Seasholtz A.F."xsd:string |
| http://purl.uniprot.org/citations/15345745 | http://purl.uniprot.org/core/author | "van der Saag P.T."xsd:string |
| http://purl.uniprot.org/citations/15345745 | http://purl.uniprot.org/core/author | "Goodenough S."xsd:string |
| http://purl.uniprot.org/citations/15345745 | http://purl.uniprot.org/core/author | "Reinders M.O."xsd:string |
| http://purl.uniprot.org/citations/15345745 | http://purl.uniprot.org/core/author | "Slycke A.J."xsd:string |
| http://purl.uniprot.org/citations/15345745 | http://purl.uniprot.org/core/author | "van de Stolpe A."xsd:string |
| http://purl.uniprot.org/citations/15345745 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15345745 | http://purl.uniprot.org/core/name | "Mol Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/15345745 | http://purl.uniprot.org/core/pages | "2908-2923"xsd:string |
| http://purl.uniprot.org/citations/15345745 | http://purl.uniprot.org/core/title | "Estrogen receptor (ER)-mediated transcriptional regulation of the human corticotropin-releasing hormone-binding protein promoter: differential effects of ERalpha and ERbeta."xsd:string |
| http://purl.uniprot.org/citations/15345745 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/15345745 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15345745 |
| http://purl.uniprot.org/citations/15345745 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15345745 |
| http://purl.uniprot.org/uniprot/Q60571#attribution-3BEB41A5553179E79585CC599E9FA56C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15345745 |
| http://purl.uniprot.org/uniprot/P24387#attribution-3BEB41A5553179E79585CC599E9FA56C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15345745 |
| http://purl.uniprot.org/uniprot/P24388#attribution-3BEB41A5553179E79585CC599E9FA56C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15345745 |
| http://purl.uniprot.org/uniprot/Q92731#attribution-3BEB41A5553179E79585CC599E9FA56C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15345745 |
| http://purl.uniprot.org/uniprot/P03372#attribution-3BEB41A5553179E79585CC599E9FA56C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15345745 |
| http://purl.uniprot.org/uniprot/P01375#attribution-3BEB41A5553179E79585CC599E9FA56C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15345745 |
| http://purl.uniprot.org/uniprot/#_A0A125SXW0-mappedCitation-15345745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15345745 |