| http://purl.uniprot.org/citations/15350217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15350217 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferon-inducible p47 GTPases are critical mediators of cell-autonomous resistance against several intracellular pathogens. Here we present the first crystal structure of a member of this novel GTPase family, IIGP1, in its nucleotide-free, GDP-, and GppNHp-bound form. The structure shows a Ras-like G domain between an N-terminal three-helix bundle and a complex system of C-terminal helices and loops. Sequence comparison and secondary structure prediction suggest the IIGP1 structure to be a valid model for the p47 GTPase family. The IIGP1 crystals contain a noncrystallographic dimer. We show that the dimer is required for cooperative GTP hydrolysis and GTP-dependent oligomerization of IIGP1. We also present the GDP- and GppNHp-bound monomeric structures of two dimer interface mutants. Our structures direct approaches to the analysis of the catalytic mechanism of IIGP1 and provide a coherent basis for structure-function studies aimed at elucidating the mechanistic basis of pathogen resistance caused by these enigmatic GTPases."xsd:string |
| http://purl.uniprot.org/citations/15350217 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2004.07.017"xsd:string |
| http://purl.uniprot.org/citations/15350217 | http://purl.uniprot.org/core/author | "Ghosh A."xsd:string |
| http://purl.uniprot.org/citations/15350217 | http://purl.uniprot.org/core/author | "Herrmann C."xsd:string |
| http://purl.uniprot.org/citations/15350217 | http://purl.uniprot.org/core/author | "Wolf E."xsd:string |
| http://purl.uniprot.org/citations/15350217 | http://purl.uniprot.org/core/author | "Howard J."xsd:string |
| http://purl.uniprot.org/citations/15350217 | http://purl.uniprot.org/core/author | "Uthaiah R."xsd:string |
| http://purl.uniprot.org/citations/15350217 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15350217 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/15350217 | http://purl.uniprot.org/core/pages | "727-739"xsd:string |
| http://purl.uniprot.org/citations/15350217 | http://purl.uniprot.org/core/title | "Crystal structure of IIGP1: a paradigm for interferon-inducible p47 resistance GTPases."xsd:string |
| http://purl.uniprot.org/citations/15350217 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/15350217 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15350217 |
| http://purl.uniprot.org/citations/15350217 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15350217 |
| http://purl.uniprot.org/uniprot/#_J7NNX8-mappedCitation-15350217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15350217 |
| http://purl.uniprot.org/uniprot/#_Q9QZ85-mappedCitation-15350217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15350217 |
| http://purl.uniprot.org/uniprot/J7NNX8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15350217 |
| http://purl.uniprot.org/uniprot/Q9QZ85 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15350217 |