| http://purl.uniprot.org/citations/15350465 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15350465 | http://www.w3.org/2000/01/rdf-schema#comment | "The minor histocompatibility antigens (mHags), HA-1 and HPA-5, are immunogenic alloantigens shown to be responsible for graft-versus-host disease (GVHD) in HLA-identical bone marrow transplantation. Both antigens have two known alleles each, resulting in a single amino acid polymorphism. The HA-1H allele encodes histidine, whereas the HA-1R allele encodes arginine. The HPA-5b (Br(a)) allele encodes lysine, whereas the HPA-5a (Br(b)) encodes glutamic acid. In this study, 49 bone marrow transplant recipients and their genetically related HLA-identical donors were evaluated for the presence of HA-1, whereas 39 recipients, different from the abovementioned ones, and their HLA-identical siblings were analyzed for the presence of HPA-5. The frequencies of the two alleles of HA-1 in the recipient population were HA-1R = 0.663 and HA-1H = 0.336. In the donor population, the respective frequencies were 0.704 and 0.296. Seven donors (14.5%) were mismatched with the recipients for HA-1H. In contrast, the frequencies of the two alleles of HPA-5 in the recipient population were HPA-5a = 0.859 and HPA-5b = 0.141; whereas, among donors, they were 0.820 and 0.180, respectively. Five donors (12.8%) were found to be mismatched with their recipients for HPA-5. These results provide insight into the polymorphism of mH antigens based on the study of their frequencies in bone marrow transplant recipients and their genetically HLA-identical siblings, an endeavor that is essential to investigate the presence of HA-1 and HPA-5 mHags."xsd:string |
| http://purl.uniprot.org/citations/15350465 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.transproceed.2004.06.007"xsd:string |
| http://purl.uniprot.org/citations/15350465 | http://purl.uniprot.org/core/author | "Stavropoulos-Giokas C."xsd:string |
| http://purl.uniprot.org/citations/15350465 | http://purl.uniprot.org/core/author | "Kalofoutis A."xsd:string |
| http://purl.uniprot.org/citations/15350465 | http://purl.uniprot.org/core/author | "Kalofoutis C."xsd:string |
| http://purl.uniprot.org/citations/15350465 | http://purl.uniprot.org/core/author | "Kotzampasaki E.M."xsd:string |
| http://purl.uniprot.org/citations/15350465 | http://purl.uniprot.org/core/author | "Spyropoulou-Vlachou M.S."xsd:string |
| http://purl.uniprot.org/citations/15350465 | http://purl.uniprot.org/core/author | "Vrani V."xsd:string |
| http://purl.uniprot.org/citations/15350465 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15350465 | http://purl.uniprot.org/core/name | "Transplant Proc"xsd:string |
| http://purl.uniprot.org/citations/15350465 | http://purl.uniprot.org/core/pages | "1735-1738"xsd:string |
| http://purl.uniprot.org/citations/15350465 | http://purl.uniprot.org/core/title | "Minor histocompatibility antigen HA-1 and HPA-5 polymorphisms in HLA-identical related bone marrow transplantation."xsd:string |
| http://purl.uniprot.org/citations/15350465 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/15350465 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15350465 |
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