| http://purl.uniprot.org/citations/15361857 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15361857 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15361857 | http://www.w3.org/2000/01/rdf-schema#comment | "Nonsense-mediated mRNA decay (NMD) in mammalian cells targets cap-binding protein 80 (CBP80)-bound mRNA during or after a pioneer round of translation. It is unknown whether eukaryotic translation initiation factor 4G (eIF4G) functions in the pioneer round. We show that baculovirus-produced CBP80 and CBP20 independently interact with eIF4GI. The interactions between eIF4G and the heterodimer CBP80/20 suggest that eIF4G has a function in the pioneer initiation complex rather than merely a presence during remodeling to the steady-state complex. First, NMD is inhibited upon eIF4G cleavage by HIV-2 or poliovirus 2A protease. Second, eIF4GI coimmunopurifies with pre-mRNA, indicating that it associates with transcripts before the pioneer round. Third, eIF4G immunopurifies with Upf NMD factors and eIF4AIII, which are constituents of the pioneer translation initiation complex. We propose a model in which eIF4G serves to connect CBP80/20 with other initiation factors during the pioneer round of translation."xsd:string |
| http://purl.uniprot.org/citations/15361857 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb824"xsd:string |
| http://purl.uniprot.org/citations/15361857 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb824"xsd:string |
| http://purl.uniprot.org/citations/15361857 | http://purl.uniprot.org/core/author | "Maquat L.E."xsd:string |
| http://purl.uniprot.org/citations/15361857 | http://purl.uniprot.org/core/author | "Maquat L.E."xsd:string |
| http://purl.uniprot.org/citations/15361857 | http://purl.uniprot.org/core/author | "Lejeune F."xsd:string |
| http://purl.uniprot.org/citations/15361857 | http://purl.uniprot.org/core/author | "Lejeune F."xsd:string |
| http://purl.uniprot.org/citations/15361857 | http://purl.uniprot.org/core/author | "Ranganathan A.C."xsd:string |
| http://purl.uniprot.org/citations/15361857 | http://purl.uniprot.org/core/author | "Ranganathan A.C."xsd:string |
| http://purl.uniprot.org/citations/15361857 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15361857 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15361857 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/15361857 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/15361857 | http://purl.uniprot.org/core/pages | "992-1000"xsd:string |
| http://purl.uniprot.org/citations/15361857 | http://purl.uniprot.org/core/pages | "992-1000"xsd:string |
| http://purl.uniprot.org/citations/15361857 | http://purl.uniprot.org/core/title | "eIF4G is required for the pioneer round of translation in mammalian cells."xsd:string |
| http://purl.uniprot.org/citations/15361857 | http://purl.uniprot.org/core/title | "eIF4G is required for the pioneer round of translation in mammalian cells."xsd:string |
| http://purl.uniprot.org/citations/15361857 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/15361857 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/15361857 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15361857 |
| http://purl.uniprot.org/citations/15361857 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15361857 |
| http://purl.uniprot.org/citations/15361857 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15361857 |
| http://purl.uniprot.org/citations/15361857 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15361857 |