| http://purl.uniprot.org/citations/15361858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15361858 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15361858 | http://www.w3.org/2000/01/rdf-schema#comment | "Genomic recoding by A-->I RNA editing plays an important role in diversifying the proteins involved in electrical excitability. Here, we describe editing of an intronless potassium channel gene. A small region of human K(V)1.1 mRNA sequence directs efficient modification of one adenosine by human adenosine deaminase acting on RNA 2 (hADAR2). Mutational analysis shows that this region adopts a hairpin structure. Electrophysiological characterization reveals that the editing event (I/V) profoundly affects channel inactivation conferred by accessory beta subunits. Drosophila melanogaster Shaker channels, mimicking this editing event through mutation, exhibit a similar effect. In addition, we demonstrate that mRNAs for the paralogous D. melanogaster Shab potassium channel are edited at the same position by fly ADAR-a clear example of convergent evolution driven by adenosine deamination. These results suggest an ancient and key regulatory role for this residue in K(V) channels."xsd:string |
| http://purl.uniprot.org/citations/15361858 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb825"xsd:string |
| http://purl.uniprot.org/citations/15361858 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb825"xsd:string |
| http://purl.uniprot.org/citations/15361858 | http://purl.uniprot.org/core/author | "Bhalla T."xsd:string |
| http://purl.uniprot.org/citations/15361858 | http://purl.uniprot.org/core/author | "Bhalla T."xsd:string |
| http://purl.uniprot.org/citations/15361858 | http://purl.uniprot.org/core/author | "Reenan R."xsd:string |
| http://purl.uniprot.org/citations/15361858 | http://purl.uniprot.org/core/author | "Reenan R."xsd:string |
| http://purl.uniprot.org/citations/15361858 | http://purl.uniprot.org/core/author | "Holmgren M."xsd:string |
| http://purl.uniprot.org/citations/15361858 | http://purl.uniprot.org/core/author | "Holmgren M."xsd:string |
| http://purl.uniprot.org/citations/15361858 | http://purl.uniprot.org/core/author | "Rosenthal J.J."xsd:string |
| http://purl.uniprot.org/citations/15361858 | http://purl.uniprot.org/core/author | "Rosenthal J.J."xsd:string |
| http://purl.uniprot.org/citations/15361858 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15361858 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15361858 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/15361858 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/15361858 | http://purl.uniprot.org/core/pages | "950-956"xsd:string |
| http://purl.uniprot.org/citations/15361858 | http://purl.uniprot.org/core/pages | "950-956"xsd:string |
| http://purl.uniprot.org/citations/15361858 | http://purl.uniprot.org/core/title | "Control of human potassium channel inactivation by editing of a small mRNA hairpin."xsd:string |
| http://purl.uniprot.org/citations/15361858 | http://purl.uniprot.org/core/title | "Control of human potassium channel inactivation by editing of a small mRNA hairpin."xsd:string |
| http://purl.uniprot.org/citations/15361858 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/15361858 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/15361858 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15361858 |
| http://purl.uniprot.org/citations/15361858 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15361858 |