| http://purl.uniprot.org/citations/15361862 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15361862 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15361862 | http://www.w3.org/2000/01/rdf-schema#comment | "The emerging antibiotics-resistance problem has underlined the urgent need for novel antimicrobial agents. Lantibiotics (lanthionine-containing antibiotics) are promising candidates to alleviate this problem. Nisin, a member of this family, has a unique pore-forming activity against bacteria. It binds to lipid II, the essential precursor of cell wall synthesis. As a result, the membrane permeabilization activity of nisin is increased by three orders of magnitude. Here we report the solution structure of the complex of nisin and lipid II. The structure shows a novel lipid II-binding motif in which the pyrophosphate moiety of lipid II is primarily coordinated by the N-terminal backbone amides of nisin via intermolecular hydrogen bonds. This cage structure provides a rationale for the conservation of the lanthionine rings among several lipid II-binding lantibiotics. The structure of the pyrophosphate cage offers a template for structure-based design of novel antibiotics."xsd:string |
| http://purl.uniprot.org/citations/15361862 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb830"xsd:string |
| http://purl.uniprot.org/citations/15361862 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb830"xsd:string |
| http://purl.uniprot.org/citations/15361862 | http://purl.uniprot.org/core/author | "van Nuland N.A."xsd:string |
| http://purl.uniprot.org/citations/15361862 | http://purl.uniprot.org/core/author | "van Nuland N.A."xsd:string |
| http://purl.uniprot.org/citations/15361862 | http://purl.uniprot.org/core/author | "Kaptein R."xsd:string |
| http://purl.uniprot.org/citations/15361862 | http://purl.uniprot.org/core/author | "Kaptein R."xsd:string |
| http://purl.uniprot.org/citations/15361862 | http://purl.uniprot.org/core/author | "Bonvin A.M."xsd:string |
| http://purl.uniprot.org/citations/15361862 | http://purl.uniprot.org/core/author | "Bonvin A.M."xsd:string |
| http://purl.uniprot.org/citations/15361862 | http://purl.uniprot.org/core/author | "Breukink E."xsd:string |
| http://purl.uniprot.org/citations/15361862 | http://purl.uniprot.org/core/author | "Breukink E."xsd:string |
| http://purl.uniprot.org/citations/15361862 | http://purl.uniprot.org/core/author | "de Kruijff B."xsd:string |
| http://purl.uniprot.org/citations/15361862 | http://purl.uniprot.org/core/author | "de Kruijff B."xsd:string |
| http://purl.uniprot.org/citations/15361862 | http://purl.uniprot.org/core/author | "Hsu S.T."xsd:string |
| http://purl.uniprot.org/citations/15361862 | http://purl.uniprot.org/core/author | "Hsu S.T."xsd:string |
| http://purl.uniprot.org/citations/15361862 | http://purl.uniprot.org/core/author | "Lutters M.A."xsd:string |
| http://purl.uniprot.org/citations/15361862 | http://purl.uniprot.org/core/author | "Lutters M.A."xsd:string |
| http://purl.uniprot.org/citations/15361862 | http://purl.uniprot.org/core/author | "Tischenko E."xsd:string |
| http://purl.uniprot.org/citations/15361862 | http://purl.uniprot.org/core/author | "Tischenko E."xsd:string |
| http://purl.uniprot.org/citations/15361862 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15361862 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15361862 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/15361862 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |