| http://purl.uniprot.org/citations/15363409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15363409 | http://www.w3.org/2000/01/rdf-schema#comment | "The anterior heart field (AHF) mediates formation of the outflow tract (OFT) and right ventricle (RV) during looping morphogenesis of the heart. Foxh1 is a forkhead DNA binding transcription factor in the TGFbeta-Smad pathway. Here we demonstrate that Foxh1-/-mutant mouse embryos form a primitive heart tube, but fail to form OFT and RV and display loss of outer curvature markers of the future working myocardium, similar to the phenotype of Mef2c-/-mutant hearts. Further, we show that Mef2c is a direct target of Foxh1, which physically and functionally interacts with Nkx2-5 to mediate strong Smad-dependent activation of a TGFbeta response element in the Mef2c gene. This element directs transgene expression to the presumptive AHF, as well as the RV and OFT, a pattern that closely parallels endogenous Mef2c expression in the heart. Thus, Foxh1 and Nkx2-5 functionally interact and are essential for development of the AHF and its derivatives, the RV and OFT, in response to TGFbeta-like signals."xsd:string |
| http://purl.uniprot.org/citations/15363409 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2004.07.023"xsd:string |
| http://purl.uniprot.org/citations/15363409 | http://purl.uniprot.org/core/author | "Lickert H."xsd:string |
| http://purl.uniprot.org/citations/15363409 | http://purl.uniprot.org/core/author | "Harvey R.P."xsd:string |
| http://purl.uniprot.org/citations/15363409 | http://purl.uniprot.org/core/author | "Attisano L."xsd:string |
| http://purl.uniprot.org/citations/15363409 | http://purl.uniprot.org/core/author | "Wrana J.L."xsd:string |
| http://purl.uniprot.org/citations/15363409 | http://purl.uniprot.org/core/author | "Walls J.R."xsd:string |
| http://purl.uniprot.org/citations/15363409 | http://purl.uniprot.org/core/author | "Rossant J."xsd:string |
| http://purl.uniprot.org/citations/15363409 | http://purl.uniprot.org/core/author | "Erdemir T."xsd:string |
| http://purl.uniprot.org/citations/15363409 | http://purl.uniprot.org/core/author | "Silvestri C."xsd:string |
| http://purl.uniprot.org/citations/15363409 | http://purl.uniprot.org/core/author | "von Both I."xsd:string |
| http://purl.uniprot.org/citations/15363409 | http://purl.uniprot.org/core/author | "Henkelman R.M."xsd:string |
| http://purl.uniprot.org/citations/15363409 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15363409 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/15363409 | http://purl.uniprot.org/core/pages | "331-345"xsd:string |
| http://purl.uniprot.org/citations/15363409 | http://purl.uniprot.org/core/title | "Foxh1 is essential for development of the anterior heart field."xsd:string |
| http://purl.uniprot.org/citations/15363409 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/15363409 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15363409 |
| http://purl.uniprot.org/citations/15363409 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15363409 |
| http://purl.uniprot.org/uniprot/O88621#attribution-3C172626119E0B804B4099E0C24D26FE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15363409 |
| http://purl.uniprot.org/uniprot/O88621#attribution-83A6319169C076628871FE123145D211 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15363409 |
| http://purl.uniprot.org/uniprot/O88621#attribution-9E81E8CC86402A3563A46457E10AE1F7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15363409 |
| http://purl.uniprot.org/uniprot/P42582#attribution-023E5B2293FD8871157C038480D7E4DD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15363409 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JDK0-mappedCitation-15363409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15363409 |