| http://purl.uniprot.org/citations/15369677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15369677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15369677 | http://www.w3.org/2000/01/rdf-schema#comment | "Wnt proteins are intercellular signals that regulate various aspects of animal development. In Caenorhabditis elegans, mutations in lin-17, a Frizzled-class Wnt receptor, and in lin-18 affect cell fate patterning in the P7.p vulval lineage. We found that lin-18 encodes a member of the Ryk/Derailed family of tyrosine kinase-related receptors, recently found to function as Wnt receptors. Members of this family have nonactive kinase domains. The LIN-18 kinase domain is dispensable for LIN-18 function, while the Wnt binding WIF domain is required. We also found that Wnt proteins LIN-44, MOM-2, and CWN-2 redundantly regulate P7.p patterning. Genetic interactions indicate that LIN-17 and LIN-18 function independently of each other in parallel pathways, and different ligands display different receptor specificities. Thus, two independent Wnt signaling pathways, one employing a Ryk receptor and the other a Frizzled receptor, function in parallel to regulate cell fate patterning in the C. elegans vulva."xsd:string |
| http://purl.uniprot.org/citations/15369677 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2004.09.001"xsd:string |
| http://purl.uniprot.org/citations/15369677 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2004.09.001"xsd:string |
| http://purl.uniprot.org/citations/15369677 | http://purl.uniprot.org/core/author | "Inoue T."xsd:string |
| http://purl.uniprot.org/citations/15369677 | http://purl.uniprot.org/core/author | "Inoue T."xsd:string |
| http://purl.uniprot.org/citations/15369677 | http://purl.uniprot.org/core/author | "Hill R.J."xsd:string |
| http://purl.uniprot.org/citations/15369677 | http://purl.uniprot.org/core/author | "Hill R.J."xsd:string |
| http://purl.uniprot.org/citations/15369677 | http://purl.uniprot.org/core/author | "Sternberg P.W."xsd:string |
| http://purl.uniprot.org/citations/15369677 | http://purl.uniprot.org/core/author | "Sternberg P.W."xsd:string |
| http://purl.uniprot.org/citations/15369677 | http://purl.uniprot.org/core/author | "Gharib S."xsd:string |
| http://purl.uniprot.org/citations/15369677 | http://purl.uniprot.org/core/author | "Gharib S."xsd:string |
| http://purl.uniprot.org/citations/15369677 | http://purl.uniprot.org/core/author | "Deshpande R."xsd:string |
| http://purl.uniprot.org/citations/15369677 | http://purl.uniprot.org/core/author | "Deshpande R."xsd:string |
| http://purl.uniprot.org/citations/15369677 | http://purl.uniprot.org/core/author | "Katz W.S."xsd:string |
| http://purl.uniprot.org/citations/15369677 | http://purl.uniprot.org/core/author | "Katz W.S."xsd:string |
| http://purl.uniprot.org/citations/15369677 | http://purl.uniprot.org/core/author | "Oz H.S."xsd:string |
| http://purl.uniprot.org/citations/15369677 | http://purl.uniprot.org/core/author | "Oz H.S."xsd:string |
| http://purl.uniprot.org/citations/15369677 | http://purl.uniprot.org/core/author | "Wiland D."xsd:string |
| http://purl.uniprot.org/citations/15369677 | http://purl.uniprot.org/core/author | "Wiland D."xsd:string |
| http://purl.uniprot.org/citations/15369677 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15369677 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15369677 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/15369677 | http://purl.uniprot.org/core/name | "Cell"xsd:string |