| http://purl.uniprot.org/citations/15369779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15369779 | http://www.w3.org/2000/01/rdf-schema#comment | "Dual-specificity tyrosine(Y) regulated kinase 1A (DYRK1A) is a serine/threonine protein kinase implicated in mental retardation resulting from Down syndrome. In this study, we carried out yeast two-hybrid screening to find proteins regulating DYRK1A kinase activity. We identified 14-3-3 as a Dyrk1A interacting protein, which is consistent with the previous finding of the interaction between the yeast orthologues Yak1p and Bmh1/2p. We showed the interaction between Dyrk1A and 14-3-3 in vitro and in vivo. The binding required the N-terminus of Dyrk1A and was independent of the Dyrk1A phosphorylation status. Functionally, 14-3-3 binding increased Dyrk1A kinase activity in a dose dependent manner in vitro. In vivo, a small peptide inhibiting 14-3-3 binding, sc138, decreased Dyrk1A kinase activity in COS7. In summary, these results suggest that DYRK1A kinase activity could be regulated by the interaction of 14-3-3."xsd:string |
| http://purl.uniprot.org/citations/15369779 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2004.08.102"xsd:string |
| http://purl.uniprot.org/citations/15369779 | http://purl.uniprot.org/core/author | "Kim Y.J."xsd:string |
| http://purl.uniprot.org/citations/15369779 | http://purl.uniprot.org/core/author | "Kang J."xsd:string |
| http://purl.uniprot.org/citations/15369779 | http://purl.uniprot.org/core/author | "Kim D."xsd:string |
| http://purl.uniprot.org/citations/15369779 | http://purl.uniprot.org/core/author | "Song W.J."xsd:string |
| http://purl.uniprot.org/citations/15369779 | http://purl.uniprot.org/core/author | "Chung S.H."xsd:string |
| http://purl.uniprot.org/citations/15369779 | http://purl.uniprot.org/core/author | "Kim G.S."xsd:string |
| http://purl.uniprot.org/citations/15369779 | http://purl.uniprot.org/core/author | "Choi S.Y."xsd:string |
| http://purl.uniprot.org/citations/15369779 | http://purl.uniprot.org/core/author | "Joe C.O."xsd:string |
| http://purl.uniprot.org/citations/15369779 | http://purl.uniprot.org/core/author | "Won J."xsd:string |
| http://purl.uniprot.org/citations/15369779 | http://purl.uniprot.org/core/author | "Shin D.W."xsd:string |
| http://purl.uniprot.org/citations/15369779 | http://purl.uniprot.org/core/author | "Hwang M.K."xsd:string |
| http://purl.uniprot.org/citations/15369779 | http://purl.uniprot.org/core/author | "Jeong B.W."xsd:string |
| http://purl.uniprot.org/citations/15369779 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15369779 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/15369779 | http://purl.uniprot.org/core/pages | "499-504"xsd:string |
| http://purl.uniprot.org/citations/15369779 | http://purl.uniprot.org/core/title | "Regulation of Dyrk1A kinase activity by 14-3-3."xsd:string |
| http://purl.uniprot.org/citations/15369779 | http://purl.uniprot.org/core/volume | "323"xsd:string |
| http://purl.uniprot.org/citations/15369779 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15369779 |
| http://purl.uniprot.org/citations/15369779 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15369779 |
| http://purl.uniprot.org/uniprot/#_Q13627-mappedCitation-15369779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15369779 |
| http://purl.uniprot.org/uniprot/#_P68511-mappedCitation-15369779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15369779 |
| http://purl.uniprot.org/uniprot/#_P62258-mappedCitation-15369779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15369779 |