| http://purl.uniprot.org/citations/15371328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15371328 | http://www.w3.org/2000/01/rdf-schema#comment | "Vascular stabilization, a process by which nascent vessels are invested with mural cells, is important in angiogenesis. Here we describe the molecular basis of vascular stabilization regulated by sphingosine 1-phosphate (S1P), a platelet-derived lipid mediator. S1P1 receptor-dependent cell-surface trafficking and activation of the cell-cell adhesion molecule N-cadherin is essential for interactions between endothelial and mural cells. Endothelial cell S1P1/Gi/Rac pathway induces microtubule polymerization, resulting in trafficking of N-cadherin to polarized plasma membrane domains. S1P treatment modulated the phosphorylation of N-cadherin as well as p120-catenin and induced the formation of cadherin/catenin/actin complexes containing novel regulatory and trafficking factors. The net result of endothelial cell S1P1 receptor activation is the proper trafficking and strengthening of N-cadherin-dependent cell-cell adhesion with mural cells. Perturbation of N-cadherin expression with small interfering RNA profoundly attenuated vascular stabilization in vitro and in vivo. S1P-induced trafficking and activation of N-cadherin provides a novel mechanism for the stabilization of nascent blood vessels by mural cells and may be exploited to control angiogenesis and vascular diseases."xsd:string |
| http://purl.uniprot.org/citations/15371328 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1227804"xsd:string |
| http://purl.uniprot.org/citations/15371328 | http://purl.uniprot.org/core/author | "Han D.K."xsd:string |
| http://purl.uniprot.org/citations/15371328 | http://purl.uniprot.org/core/author | "Proia R.L."xsd:string |
| http://purl.uniprot.org/citations/15371328 | http://purl.uniprot.org/core/author | "Hla T."xsd:string |
| http://purl.uniprot.org/citations/15371328 | http://purl.uniprot.org/core/author | "Paik J.H."xsd:string |
| http://purl.uniprot.org/citations/15371328 | http://purl.uniprot.org/core/author | "Chae S.S."xsd:string |
| http://purl.uniprot.org/citations/15371328 | http://purl.uniprot.org/core/author | "Cowan A.E."xsd:string |
| http://purl.uniprot.org/citations/15371328 | http://purl.uniprot.org/core/author | "Skoura A."xsd:string |
| http://purl.uniprot.org/citations/15371328 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15371328 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/15371328 | http://purl.uniprot.org/core/pages | "2392-2403"xsd:string |
| http://purl.uniprot.org/citations/15371328 | http://purl.uniprot.org/core/title | "Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization."xsd:string |
| http://purl.uniprot.org/citations/15371328 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/15371328 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15371328 |
| http://purl.uniprot.org/citations/15371328 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15371328 |
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| http://purl.uniprot.org/uniprot/#_A0A494B9T3-mappedCitation-15371328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15371328 |
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| http://purl.uniprot.org/uniprot/#_B1ARB3-mappedCitation-15371328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15371328 |
| http://purl.uniprot.org/uniprot/#_O08530-mappedCitation-15371328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15371328 |
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