| http://purl.uniprot.org/citations/15372073 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15372073 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15372073 | http://www.w3.org/2000/01/rdf-schema#comment | "Tissue plasminogen activator (tPA) is a serine protease involved in the degradation of blood clots through the activation of plasminogen to plasmin. Here we report on the identification of tPA as a specific protease able to activate platelet-derived growth factor C (PDGF-C). The newly identified PDGF-C is secreted as a latent dimeric factor (PDGF-CC) that upon proteolytic removal of the N-terminal CUB domains becomes a PDGF receptor alpha agonist. The CUB domains in PDGF-CC directly interact with tPA, and fibroblasts from tPA-deficient mice fail to activate latent PDGF-CC. We further demonstrate that growth of primary fibroblasts in culture is dependent on a tPA-mediated cleavage of latent PDGF-CC, generating a growth stimulatory loop. Immunohistochemical analysis showed similar expression patterns of PDGF-C and tPA in developing mouse embryos and in tumors, indicating both autocrine and paracrine modes of activation of PDGF receptor-mediated signaling pathways. The identification of tPA as an activator of PDGF signaling establishes a novel role for the protease in normal and pathological tissue growth and maintenance, distinct from its well-known role in plasminogen activation and fibrinolysis."xsd:string |
| http://purl.uniprot.org/citations/15372073 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600397"xsd:string |
| http://purl.uniprot.org/citations/15372073 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600397"xsd:string |
| http://purl.uniprot.org/citations/15372073 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/15372073 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/15372073 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/15372073 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/15372073 | http://purl.uniprot.org/core/author | "Eriksson U."xsd:string |
| http://purl.uniprot.org/citations/15372073 | http://purl.uniprot.org/core/author | "Eriksson U."xsd:string |
| http://purl.uniprot.org/citations/15372073 | http://purl.uniprot.org/core/author | "Fieber C."xsd:string |
| http://purl.uniprot.org/citations/15372073 | http://purl.uniprot.org/core/author | "Fieber C."xsd:string |
| http://purl.uniprot.org/citations/15372073 | http://purl.uniprot.org/core/author | "Fredriksson L."xsd:string |
| http://purl.uniprot.org/citations/15372073 | http://purl.uniprot.org/core/author | "Fredriksson L."xsd:string |
| http://purl.uniprot.org/citations/15372073 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15372073 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15372073 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/15372073 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/15372073 | http://purl.uniprot.org/core/pages | "3793-3802"xsd:string |
| http://purl.uniprot.org/citations/15372073 | http://purl.uniprot.org/core/pages | "3793-3802"xsd:string |
| http://purl.uniprot.org/citations/15372073 | http://purl.uniprot.org/core/title | "Tissue plasminogen activator is a potent activator of PDGF-CC."xsd:string |
| http://purl.uniprot.org/citations/15372073 | http://purl.uniprot.org/core/title | "Tissue plasminogen activator is a potent activator of PDGF-CC."xsd:string |
| http://purl.uniprot.org/citations/15372073 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/15372073 | http://purl.uniprot.org/core/volume | "23"xsd:string |