| http://purl.uniprot.org/citations/15375157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15375157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15375157 | http://www.w3.org/2000/01/rdf-schema#comment | "To look for regulators of the mitogen-activated protein kinase (MAPK) kinase 6 (MKK6), a yeast two-hybrid screen was initiated using MKK6 as bait. p150(Glued) dynactin, a key component of the cytoplasmic dynein-dynactin motor complex, was found to specifically interact with MKK6 and its close homologue MKK3. Silencing of p150(Glued) expression by small interference RNA reduced the stimulus-induced phosphorylation of MKK3/6 and p38 MAPKs. The similar adverse effect was also seen when the cytoplasmic dynein motor was disrupted by other means. Like p150(Glued), MKK3/6 directly associate with microtubules. Disruption of microtubules prior to cell stimulation specifically inhibits the stimulus-induced phosphorylation of both MKK3/6 and p38 MAPKs. Our unexpected findings reveal a specific requirement for p150(Glued)/dynein/functional microtubules in activation of MKK3/6 and p38 MAPKs in vivo."xsd:string |
| http://purl.uniprot.org/citations/15375157 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c400333200"xsd:string |
| http://purl.uniprot.org/citations/15375157 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.c400333200"xsd:string |
| http://purl.uniprot.org/citations/15375157 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/15375157 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/15375157 | http://purl.uniprot.org/core/author | "Lin S."xsd:string |
| http://purl.uniprot.org/citations/15375157 | http://purl.uniprot.org/core/author | "Lin S."xsd:string |
| http://purl.uniprot.org/citations/15375157 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/15375157 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/15375157 | http://purl.uniprot.org/core/author | "Wu Z."xsd:string |
| http://purl.uniprot.org/citations/15375157 | http://purl.uniprot.org/core/author | "Wu Z."xsd:string |
| http://purl.uniprot.org/citations/15375157 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/15375157 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/15375157 | http://purl.uniprot.org/core/author | "Long J."xsd:string |
| http://purl.uniprot.org/citations/15375157 | http://purl.uniprot.org/core/author | "Long J."xsd:string |
| http://purl.uniprot.org/citations/15375157 | http://purl.uniprot.org/core/author | "Cheung P.Y."xsd:string |
| http://purl.uniprot.org/citations/15375157 | http://purl.uniprot.org/core/author | "Cheung P.Y."xsd:string |
| http://purl.uniprot.org/citations/15375157 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15375157 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15375157 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15375157 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15375157 | http://purl.uniprot.org/core/pages | "45308-45311"xsd:string |
| http://purl.uniprot.org/citations/15375157 | http://purl.uniprot.org/core/pages | "45308-45311"xsd:string |