| http://purl.uniprot.org/citations/15377996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15377996 | http://www.w3.org/2000/01/rdf-schema#comment | "Polycomb group (Pc-G) proteins associate to form large complexes that repress Hox genes, thereby imposing Hox gene expression pattern required for development. However, Pc-G proteins have a Hox-independent function in controlling cell proliferation. Here we show that embryonic fibroblasts derived from M33-deficient mice are impaired in the progression into the S phase of the cell cycle, as shown by a reduced rate of incorporation of bromodeoxyuridine. These cells have a senescent phenotype, associated to an abnormal accumulation of the cyclin-dependent kinase inhibitor p16INK4a protein. We demonstrate that this defect is bypassed in mutant embryonic fibroblasts expressing a transdominant negative form of the cell cycle controlling transcription factor E2F (E2F-DB). In addition, we show that the polycomb protein M33 controls critical expansion of B- and T-lymphocyte precursors. Together, our results emphasize M33-Polycomb protein function in cell cycle control."xsd:string |
| http://purl.uniprot.org/citations/15377996 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1207998"xsd:string |
| http://purl.uniprot.org/citations/15377996 | http://purl.uniprot.org/core/author | "Joly F."xsd:string |
| http://purl.uniprot.org/citations/15377996 | http://purl.uniprot.org/core/author | "Djabali M."xsd:string |
| http://purl.uniprot.org/citations/15377996 | http://purl.uniprot.org/core/author | "Core N."xsd:string |
| http://purl.uniprot.org/citations/15377996 | http://purl.uniprot.org/core/author | "Boned A."xsd:string |
| http://purl.uniprot.org/citations/15377996 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15377996 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/15377996 | http://purl.uniprot.org/core/pages | "7660-7668"xsd:string |
| http://purl.uniprot.org/citations/15377996 | http://purl.uniprot.org/core/title | "Disruption of E2F signaling suppresses the INK4a-induced proliferative defect in M33-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/15377996 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/15377996 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15377996 |
| http://purl.uniprot.org/citations/15377996 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15377996 |
| http://purl.uniprot.org/uniprot/#_A7LP29-mappedCitation-15377996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15377996 |
| http://purl.uniprot.org/uniprot/#_Q64364-mappedCitation-15377996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15377996 |
| http://purl.uniprot.org/uniprot/#_Q3TZG6-mappedCitation-15377996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15377996 |
| http://purl.uniprot.org/uniprot/#_Q3URA3-mappedCitation-15377996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15377996 |
| http://purl.uniprot.org/uniprot/#_P30658-mappedCitation-15377996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15377996 |
| http://purl.uniprot.org/uniprot/#_P51480-mappedCitation-15377996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15377996 |
| http://purl.uniprot.org/uniprot/#_Q61501-mappedCitation-15377996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15377996 |
| http://purl.uniprot.org/uniprot/#_Q78E71-mappedCitation-15377996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15377996 |
| http://purl.uniprot.org/uniprot/#_Q547J6-mappedCitation-15377996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15377996 |
| http://purl.uniprot.org/uniprot/#_Q571G3-mappedCitation-15377996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15377996 |
| http://purl.uniprot.org/uniprot/#_Q9CYB4-mappedCitation-15377996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15377996 |