| http://purl.uniprot.org/citations/15378030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15378030 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15378030 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified a novel mechanism of cross-talk between cell signaling and metabolic pathways, whereby the signaling kinase p21-activated kinase 1 (Pak1) binds to, phosphorylates and enhances the enzymatic activity of phosphoglucomutase 1 (PGM), an important regulatory enzyme in cellular glucose utilization and energy homeostasis. Pak1 and PGM were colocalized in model cell systems and showed functional interactions in a physiological setting. Strong direct interaction of PGM with Pak1 but not Pak2, Pak3, or Pak4 was observed. PGM binding was within 75-149 amino acids (aa) of Pak1, while Pak1 binding to PGM was in the N-terminal 96 aa. Pak1-mediated phosphorylation of PGM selectively on threonine 466 significantly increased PGM enzymatic activity and could be blocked by transfection with a dominant-negative Pak1 expression vector and by Pak1-specific small inhibitory RNA. Stable transfection of PGM into PGM-deficient K562 leukemia cells further demonstrated the role of Pak1 in regulating PGM activity. The results presented here provide new evidence that the cell signaling kinase Pak1 is a novel regulator of glucose metabolism through its phosphorylation and regulation of PGM activity. These findings suggest a new mechanism whereby growth factor signaling may coordinately integrate metabolic regulation with established signaling functions of cell cycle regulation and cell growth."xsd:string |
| http://purl.uniprot.org/citations/15378030 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1207969"xsd:string |
| http://purl.uniprot.org/citations/15378030 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1207969"xsd:string |
| http://purl.uniprot.org/citations/15378030 | http://purl.uniprot.org/core/author | "Kumar R."xsd:string |
| http://purl.uniprot.org/citations/15378030 | http://purl.uniprot.org/core/author | "Kumar R."xsd:string |
| http://purl.uniprot.org/citations/15378030 | http://purl.uniprot.org/core/author | "Gururaj A."xsd:string |
| http://purl.uniprot.org/citations/15378030 | http://purl.uniprot.org/core/author | "Gururaj A."xsd:string |
| http://purl.uniprot.org/citations/15378030 | http://purl.uniprot.org/core/author | "Vadlamudi R.K."xsd:string |
| http://purl.uniprot.org/citations/15378030 | http://purl.uniprot.org/core/author | "Vadlamudi R.K."xsd:string |
| http://purl.uniprot.org/citations/15378030 | http://purl.uniprot.org/core/author | "Barnes C.J."xsd:string |
| http://purl.uniprot.org/citations/15378030 | http://purl.uniprot.org/core/author | "Barnes C.J."xsd:string |
| http://purl.uniprot.org/citations/15378030 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15378030 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15378030 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/15378030 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/15378030 | http://purl.uniprot.org/core/pages | "8118-8127"xsd:string |
| http://purl.uniprot.org/citations/15378030 | http://purl.uniprot.org/core/pages | "8118-8127"xsd:string |
| http://purl.uniprot.org/citations/15378030 | http://purl.uniprot.org/core/title | "Regulation of phosphoglucomutase 1 phosphorylation and activity by a signaling kinase."xsd:string |
| http://purl.uniprot.org/citations/15378030 | http://purl.uniprot.org/core/title | "Regulation of phosphoglucomutase 1 phosphorylation and activity by a signaling kinase."xsd:string |
| http://purl.uniprot.org/citations/15378030 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/15378030 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/15378030 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15378030 |
| http://purl.uniprot.org/citations/15378030 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15378030 |