| http://purl.uniprot.org/citations/15381255 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15381255 | http://www.w3.org/2000/01/rdf-schema#comment | "Recently, it has been shown that PKA-mediated phosphorylation of the beta(2)-adrenergic receptor (beta(2)-AR) by the cyclic AMP-dependent protein kinase (PKA) reduces its affinity for G(s) and increases its affinity for G(i). Here we demonstrate that, like the beta(2)-AR, the beta(1)-AR is also capable of "switching" its coupling from G(s) to G(i) in a PKA-dependent manner. The beta(1)-AR is capable of activating adenylate cyclase via G(s), and can also activate the extracellular-regulated kinases, p44 and p42 (ERK1/2). In transfected CHO cells, the observed beta(1)-AR-mediated activation of ERK is both sensitive to pertussis toxin (PTX), indicating involvement of G(i)/G(o), and to the PKA inhibitor, H-89. beta(1)-ARs with PKA phosphorylation sites mutated to alanines are unable to activate ERK. Mutating these same residues to aspartic acid, mimicking PKA phosphorylation, leads to a decrease in G(s)-stimulated cAMP accumulation and an increase in PTX-sensitive ERK activation. These results strongly support the hypothesis that the beta(1)-AR, like the beta(2)-AR, can undergo PKA-dependent "G(s)/G(i) switching"."xsd:string |
| http://purl.uniprot.org/citations/15381255 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2004.05.002"xsd:string |
| http://purl.uniprot.org/citations/15381255 | http://purl.uniprot.org/core/author | "Lefkowitz R.J."xsd:string |
| http://purl.uniprot.org/citations/15381255 | http://purl.uniprot.org/core/author | "Whalen E.J."xsd:string |
| http://purl.uniprot.org/citations/15381255 | http://purl.uniprot.org/core/author | "Pierce K.L."xsd:string |
| http://purl.uniprot.org/citations/15381255 | http://purl.uniprot.org/core/author | "Martin N.P."xsd:string |
| http://purl.uniprot.org/citations/15381255 | http://purl.uniprot.org/core/author | "Zamah M.A."xsd:string |
| http://purl.uniprot.org/citations/15381255 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15381255 | http://purl.uniprot.org/core/name | "Cell Signal"xsd:string |
| http://purl.uniprot.org/citations/15381255 | http://purl.uniprot.org/core/pages | "1397-1403"xsd:string |
| http://purl.uniprot.org/citations/15381255 | http://purl.uniprot.org/core/title | "PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching."xsd:string |
| http://purl.uniprot.org/citations/15381255 | http://purl.uniprot.org/core/volume | "16"xsd:string |
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