| http://purl.uniprot.org/citations/15383592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15383592 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein kinase C (PKC) plays a prominent role in immune signaling. To elucidate the signal transduction in a respiratory burst and isoform-specific function of PKC during FcgammaR-mediated phagocytosis, we used live, digital fluorescence imaging of mouse microglial cells expressing GFP-tagged molecules. betaI PKC, epsilonPKC, and diacylglycerol kinase (DGK) beta dynamically and transiently accumulated around IgG-opsonized beads (BIgG). Moreover, the accumulation of p47(phox), an essential cytosolic component of NADPH oxidase and a substrate for betaI PKC, at the phagosomal cup/phagosome was apparent during BIgG ingestion. Superoxide (O(2)(-)) production was profoundly inhibited by Gö6976, a cPKC inhibitor, and dramatically increased by the DGK inhibitor, R59949. Ultrastructural analysis revealed that BIgG induced O(2)(-) production at the phagosome but not at the intracellular granules. We conclude that activation/accumulation of betaI PKC is involved in O(2)(-) production, and that O(2)(-) production is primarily initiated at the phagosomal cup/phagosome. This study also suggests that DGKbeta plays a prominent role in regulation of O(2)(-) production during FcgammaR-mediated phagocytosis."xsd:string |
| http://purl.uniprot.org/citations/15383592 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.173.7.4582"xsd:string |
| http://purl.uniprot.org/citations/15383592 | http://purl.uniprot.org/core/author | "Kobayashi T."xsd:string |
| http://purl.uniprot.org/citations/15383592 | http://purl.uniprot.org/core/author | "Hayashi S."xsd:string |
| http://purl.uniprot.org/citations/15383592 | http://purl.uniprot.org/core/author | "Shirai Y."xsd:string |
| http://purl.uniprot.org/citations/15383592 | http://purl.uniprot.org/core/author | "Saito N."xsd:string |
| http://purl.uniprot.org/citations/15383592 | http://purl.uniprot.org/core/author | "Sawada M."xsd:string |
| http://purl.uniprot.org/citations/15383592 | http://purl.uniprot.org/core/author | "Yamasaki T."xsd:string |
| http://purl.uniprot.org/citations/15383592 | http://purl.uniprot.org/core/author | "Sakai N."xsd:string |
| http://purl.uniprot.org/citations/15383592 | http://purl.uniprot.org/core/author | "Noda Y."xsd:string |
| http://purl.uniprot.org/citations/15383592 | http://purl.uniprot.org/core/author | "Ueyama T."xsd:string |
| http://purl.uniprot.org/citations/15383592 | http://purl.uniprot.org/core/author | "Lennartz M.R."xsd:string |
| http://purl.uniprot.org/citations/15383592 | http://purl.uniprot.org/core/author | "Sumimoto H."xsd:string |
| http://purl.uniprot.org/citations/15383592 | http://purl.uniprot.org/core/author | "Rikitake K."xsd:string |
| http://purl.uniprot.org/citations/15383592 | http://purl.uniprot.org/core/author | "Seguchi H."xsd:string |
| http://purl.uniprot.org/citations/15383592 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15383592 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15383592 | http://purl.uniprot.org/core/pages | "4582-4589"xsd:string |
| http://purl.uniprot.org/citations/15383592 | http://purl.uniprot.org/core/title | "Superoxide production at phagosomal cup/phagosome through beta I protein kinase C during Fc gamma R-mediated phagocytosis in microglia."xsd:string |
| http://purl.uniprot.org/citations/15383592 | http://purl.uniprot.org/core/volume | "173"xsd:string |
| http://purl.uniprot.org/citations/15383592 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15383592 |
| http://purl.uniprot.org/citations/15383592 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15383592 |
| http://purl.uniprot.org/uniprot/#_D3Z7E4-mappedCitation-15383592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15383592 |
| http://purl.uniprot.org/uniprot/#_D3Z0V6-mappedCitation-15383592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15383592 |