| http://purl.uniprot.org/citations/15385626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15385626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15385626 | http://www.w3.org/2000/01/rdf-schema#comment | "Small GTPases of the ADP-ribosylation factor (ARF) family play a key role in membrane trafficking by regulating coated vesicle formation, and guanine nucleotide exchange is essential for the ARF function. Brefeldin A blocks the ARF-triggered coat assembly by inhibiting the guanine nucleotide exchange on ARFs and causes disintegration of the Golgi complex and tubulation of endosomal membranes. BIG2 is one of brefeldin A-inhibited guanine nucleotide exchange factors for the ARF GTPases and is associated mainly with the trans-Golgi network. In the present study, we have revealed that another population of BIG2 is associated with the recycling endosome and found that expression of a catalytically inactive BIG2 mutant, E738K, selectively induces membrane tubules from this compartment. We also have shown that BIG2 has an exchange activity toward class I ARFs (ARF1 and ARF3) in vivo and inactivation of either ARF exaggerates the BIG2(E738K)-induced tubulation of endosomal membranes. These observations together indicate that BIG2 is implicated in the structural integrity of the recycling endosome through activating class I ARFs."xsd:string |
| http://purl.uniprot.org/citations/15385626 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e04-05-0388"xsd:string |
| http://purl.uniprot.org/citations/15385626 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e04-05-0388"xsd:string |
| http://purl.uniprot.org/citations/15385626 | http://purl.uniprot.org/core/author | "Nakayama K."xsd:string |
| http://purl.uniprot.org/citations/15385626 | http://purl.uniprot.org/core/author | "Nakayama K."xsd:string |
| http://purl.uniprot.org/citations/15385626 | http://purl.uniprot.org/core/author | "Noda M."xsd:string |
| http://purl.uniprot.org/citations/15385626 | http://purl.uniprot.org/core/author | "Noda M."xsd:string |
| http://purl.uniprot.org/citations/15385626 | http://purl.uniprot.org/core/author | "Shin H.W."xsd:string |
| http://purl.uniprot.org/citations/15385626 | http://purl.uniprot.org/core/author | "Shin H.W."xsd:string |
| http://purl.uniprot.org/citations/15385626 | http://purl.uniprot.org/core/author | "Morinaga N."xsd:string |
| http://purl.uniprot.org/citations/15385626 | http://purl.uniprot.org/core/author | "Morinaga N."xsd:string |
| http://purl.uniprot.org/citations/15385626 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15385626 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15385626 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/15385626 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/15385626 | http://purl.uniprot.org/core/pages | "5283-5294"xsd:string |
| http://purl.uniprot.org/citations/15385626 | http://purl.uniprot.org/core/pages | "5283-5294"xsd:string |
| http://purl.uniprot.org/citations/15385626 | http://purl.uniprot.org/core/title | "BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: its localization to recycling endosomes and implication in the endosome integrity."xsd:string |
| http://purl.uniprot.org/citations/15385626 | http://purl.uniprot.org/core/title | "BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: its localization to recycling endosomes and implication in the endosome integrity."xsd:string |
| http://purl.uniprot.org/citations/15385626 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/15385626 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/15385626 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15385626 |
| http://purl.uniprot.org/citations/15385626 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15385626 |