| http://purl.uniprot.org/citations/15386212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15386212 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15386212 | http://www.w3.org/2000/01/rdf-schema#comment | "Schizophrenia, schizoaffective disorder, and bipolar disorder are common psychiatric disorders with high heritabilities and variable phenotypes. The Disrupted in Schizophrenia 1 (DISC1) gene, on chromosome 1q42, was originally discovered and linked to schizophrenia in a Scottish kindred carrying a balanced translocation that disrupts DISC1 and DISC2. More recently, DISC1 was linked to schizophrenia, broadly defined, in the general Finnish population, through the undertransmission to affected women of a common haplotype from the region of intron 1/exon 2. We present data from a case-control study of a North American white population, confirming the underrepresentation of a common haplotype of the intron 1/exon 2 region in individuals with schizoaffective disorder. Multiple haplotypes contained within four haplotype blocks extending between exon 1 and exon 9 are associated with schizophrenia, schizoaffective disorder, and bipolar disorder. We also find overrepresentation of the exon 9 missense allele Phe607 in schizoaffective disorder. These data support the idea that these apparently distinct disorders have at least a partially convergent etiology and that variation at the DISC1 locus predisposes individuals to a variety of psychiatric disorders."xsd:string |
| http://purl.uniprot.org/citations/15386212 | http://purl.org/dc/terms/identifier | "doi:10.1086/425586"xsd:string |
| http://purl.uniprot.org/citations/15386212 | http://purl.org/dc/terms/identifier | "doi:10.1086/425586"xsd:string |
| http://purl.uniprot.org/citations/15386212 | http://purl.uniprot.org/core/author | "Goldman D."xsd:string |
| http://purl.uniprot.org/citations/15386212 | http://purl.uniprot.org/core/author | "Goldman D."xsd:string |
| http://purl.uniprot.org/citations/15386212 | http://purl.uniprot.org/core/author | "Hodgkinson C.A."xsd:string |
| http://purl.uniprot.org/citations/15386212 | http://purl.uniprot.org/core/author | "Hodgkinson C.A."xsd:string |
| http://purl.uniprot.org/citations/15386212 | http://purl.uniprot.org/core/author | "Jaeger J."xsd:string |
| http://purl.uniprot.org/citations/15386212 | http://purl.uniprot.org/core/author | "Jaeger J."xsd:string |
| http://purl.uniprot.org/citations/15386212 | http://purl.uniprot.org/core/author | "Lipsky R.H."xsd:string |
| http://purl.uniprot.org/citations/15386212 | http://purl.uniprot.org/core/author | "Lipsky R.H."xsd:string |
| http://purl.uniprot.org/citations/15386212 | http://purl.uniprot.org/core/author | "Kane J.M."xsd:string |
| http://purl.uniprot.org/citations/15386212 | http://purl.uniprot.org/core/author | "Kane J.M."xsd:string |
| http://purl.uniprot.org/citations/15386212 | http://purl.uniprot.org/core/author | "Malhotra A.K."xsd:string |
| http://purl.uniprot.org/citations/15386212 | http://purl.uniprot.org/core/author | "Malhotra A.K."xsd:string |
| http://purl.uniprot.org/citations/15386212 | http://purl.uniprot.org/core/author | "Persaud S."xsd:string |
| http://purl.uniprot.org/citations/15386212 | http://purl.uniprot.org/core/author | "Persaud S."xsd:string |
| http://purl.uniprot.org/citations/15386212 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15386212 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15386212 | http://purl.uniprot.org/core/name | "Am. J. Hum. Genet."xsd:string |
| http://purl.uniprot.org/citations/15386212 | http://purl.uniprot.org/core/name | "Am. J. Hum. Genet."xsd:string |
| http://purl.uniprot.org/citations/15386212 | http://purl.uniprot.org/core/pages | "862-872"xsd:string |
| http://purl.uniprot.org/citations/15386212 | http://purl.uniprot.org/core/pages | "862-872"xsd:string |