| http://purl.uniprot.org/citations/1538753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1538753 | http://www.w3.org/2000/01/rdf-schema#comment | "The murine major histocompatibility complex (MHC) contains two genes (Ham-1 and Ham-2) that encode members of a super-family of ATP-dependent transport proteins. These genes are believed to mediate the transport of peptide antigen from the cytoplasm into the lumen of the endoplasmic reticulum for binding by MHC class I molecules. Evidence for such a function has come from the rescue of class I surface expression by a cloned copy of the human homologue of Ham-1, PSF-1, in a human cell line that is defective in antigen processing. A mutant murine cell line, RMA-S, has an identical antigen-processing-defective phenotype. Here we show that expression of a cloned copy of the Ham-2 gene in RMA-S cells results in recovery of the ability to process and present class I-restricted antigens to cytotoxic T lymphocytes, and in partial recovery of class I surface expression. Processing defects for classical (H-2 K and D) and non-classical (Qa1 and HMT) class I molecules are corrected by Ham-2. These data indicate that both MHC-linked transporter genes are probably required for class I antigen processing, and that the functional transporter in this pathway may consist of a Ham-1/Ham-2 heterodimer."xsd:string |
| http://purl.uniprot.org/citations/1538753 | http://purl.org/dc/terms/identifier | "doi:10.1038/355647a0"xsd:string |
| http://purl.uniprot.org/citations/1538753 | http://purl.uniprot.org/core/author | "Monaco J.J."xsd:string |
| http://purl.uniprot.org/citations/1538753 | http://purl.uniprot.org/core/author | "Hermel E."xsd:string |
| http://purl.uniprot.org/citations/1538753 | http://purl.uniprot.org/core/author | "Lindahl K.F."xsd:string |
| http://purl.uniprot.org/citations/1538753 | http://purl.uniprot.org/core/author | "Aldrich C."xsd:string |
| http://purl.uniprot.org/citations/1538753 | http://purl.uniprot.org/core/author | "Bevan M.J."xsd:string |
| http://purl.uniprot.org/citations/1538753 | http://purl.uniprot.org/core/author | "Attaya M."xsd:string |
| http://purl.uniprot.org/citations/1538753 | http://purl.uniprot.org/core/author | "Forman J."xsd:string |
| http://purl.uniprot.org/citations/1538753 | http://purl.uniprot.org/core/author | "Martinez C.K."xsd:string |
| http://purl.uniprot.org/citations/1538753 | http://purl.uniprot.org/core/author | "Jameson S."xsd:string |
| http://purl.uniprot.org/citations/1538753 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1538753 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/1538753 | http://purl.uniprot.org/core/pages | "647-649"xsd:string |
| http://purl.uniprot.org/citations/1538753 | http://purl.uniprot.org/core/title | "Ham-2 corrects the class I antigen-processing defect in RMA-S cells."xsd:string |
| http://purl.uniprot.org/citations/1538753 | http://purl.uniprot.org/core/volume | "355"xsd:string |
| http://purl.uniprot.org/citations/1538753 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1538753 |
| http://purl.uniprot.org/citations/1538753 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1538753 |
| http://purl.uniprot.org/uniprot/P01887#attribution-1C76B1D86FD109017FB11E68DB755113 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1538753 |
| http://purl.uniprot.org/uniprot/P01895#attribution-1C76B1D86FD109017FB11E68DB755113 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1538753 |
| http://purl.uniprot.org/uniprot/P14427#attribution-1C76B1D86FD109017FB11E68DB755113 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1538753 |
| http://purl.uniprot.org/uniprot/P14428#attribution-1C76B1D86FD109017FB11E68DB755113 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1538753 |
| http://purl.uniprot.org/uniprot/P01901#attribution-1C76B1D86FD109017FB11E68DB755113 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1538753 |
| http://purl.uniprot.org/uniprot/P06339#attribution-1C76B1D86FD109017FB11E68DB755113 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1538753 |