| http://purl.uniprot.org/citations/15387822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15387822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15387822 | http://www.w3.org/2000/01/rdf-schema#comment | "Iron, an essential element for almost every organism, serves as a regulatory signal for the expression of virulence determinants in many prokaryotic and eukaryotic pathogens. Using a custom Affymetrix GeneChip representing the entire Candida albicans genome, we examined the changes in genome-wide gene expression in this opportunistic pathogen as a function of alterations in environmental concentrations of iron. A total of 526 open reading frame (ORF) transcripts are more highly expressed when the levels of available iron are low, while 626 ORF transcripts are more highly expressed in high-iron conditions. The transcripts dominantly affected by iron concentration range from those associated with cell-surface properties to others which affect mitochondrial function, iron transport and virulence-related secreted hydrolases. Moreover gene expression as assayed in DNA microarrays confirms and extends reports of alterations in cell-surface antigens and drug sensitivity correlated with iron availability. To understand how these genes and pathways might be regulated, we isolated a gene designated SFU1 that encodes a homologue of the Ustilago maydis URBS1, a transcriptional repressor of siderophore uptake/biosynthesis. Comparisons between wild-type and SFU1-null mutant strains revealed 139 potential target genes of Sfu1p; many of which are iron-responsive. Together, these results not only expand our understanding of global iron regulation in C. albicans, but also provide insights into the potential role of iron availability in C. albicans virulence."xsd:string |
| http://purl.uniprot.org/citations/15387822 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2958.2004.04214.x"xsd:string |
| http://purl.uniprot.org/citations/15387822 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2958.2004.04214.x"xsd:string |
| http://purl.uniprot.org/citations/15387822 | http://purl.uniprot.org/core/author | "Agabian N."xsd:string |
| http://purl.uniprot.org/citations/15387822 | http://purl.uniprot.org/core/author | "Agabian N."xsd:string |
| http://purl.uniprot.org/citations/15387822 | http://purl.uniprot.org/core/author | "Davis R.W."xsd:string |
| http://purl.uniprot.org/citations/15387822 | http://purl.uniprot.org/core/author | "Davis R.W."xsd:string |
| http://purl.uniprot.org/citations/15387822 | http://purl.uniprot.org/core/author | "Jones T."xsd:string |
| http://purl.uniprot.org/citations/15387822 | http://purl.uniprot.org/core/author | "Jones T."xsd:string |
| http://purl.uniprot.org/citations/15387822 | http://purl.uniprot.org/core/author | "Newport G."xsd:string |
| http://purl.uniprot.org/citations/15387822 | http://purl.uniprot.org/core/author | "Newport G."xsd:string |
| http://purl.uniprot.org/citations/15387822 | http://purl.uniprot.org/core/author | "Dungan J."xsd:string |
| http://purl.uniprot.org/citations/15387822 | http://purl.uniprot.org/core/author | "Dungan J."xsd:string |
| http://purl.uniprot.org/citations/15387822 | http://purl.uniprot.org/core/author | "Murillo L.A."xsd:string |
| http://purl.uniprot.org/citations/15387822 | http://purl.uniprot.org/core/author | "Murillo L.A."xsd:string |
| http://purl.uniprot.org/citations/15387822 | http://purl.uniprot.org/core/author | "Lan C.Y."xsd:string |
| http://purl.uniprot.org/citations/15387822 | http://purl.uniprot.org/core/author | "Lan C.Y."xsd:string |
| http://purl.uniprot.org/citations/15387822 | http://purl.uniprot.org/core/author | "Rodarte G."xsd:string |
| http://purl.uniprot.org/citations/15387822 | http://purl.uniprot.org/core/author | "Rodarte G."xsd:string |
| http://purl.uniprot.org/citations/15387822 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15387822 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15387822 | http://purl.uniprot.org/core/name | "Mol. Microbiol."xsd:string |
| http://purl.uniprot.org/citations/15387822 | http://purl.uniprot.org/core/name | "Mol. Microbiol."xsd:string |