| http://purl.uniprot.org/citations/1540549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1540549 | http://www.w3.org/2000/01/rdf-schema#comment | "Transgenic mice carrying a MHC class I structural gene (H-2Kb) linked to transcriptional control elements from the human beta-globin gene, which direct erythroid lineage specific transcription, express H-2Kb molecules in red blood cells but H-2Kb expression cannot be detected in skin or lymphoid cells. This limited pattern of self MHC expression is sufficient to induce tolerance to H-2Kb molecules and H-2Kb restricted cytotoxic T cell responses can be generated in transgenic mice. Transgenic mice are unable to mount H-2Kb specific cytotoxic T cell responses in vitro, even when exogenous IL-2 is provided. However, H-2Kb specific T cell proliferative responses are comparable with H-2Kb specific responses in non-transgenic mice, even in the absence of exogenous IL-2. Thus, expression of H-2Kb molecules under control of human beta-globin transcriptional control elements in transgenic mice is tolerogenic but does not result in elimination of all H-2Kb reactive T cells from the mature repertoire. This suggests that tolerance in these mice may arise due to functional inactivation of H-2Kb reactive T cells in vivo when they encounter H-2Kb molecules expressed on cells of erythroid cell lineages or on non-erythroid cells which express H-2Kb molecules at very low levels or in a developmentally regulated pattern. Furthermore, in spite of the failure to detect H-2Kb expression on non-erythroid cells in these mice, we conclude that H-2Kb molecules participate in positive selection of the T cell repertoire since H-2Kb restricted T cell responses can be generated in these transgenic mice."xsd:string |
| http://purl.uniprot.org/citations/1540549 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/4.1.59"xsd:string |
| http://purl.uniprot.org/citations/1540549 | http://purl.uniprot.org/core/author | "Mellor A.L."xsd:string |
| http://purl.uniprot.org/citations/1540549 | http://purl.uniprot.org/core/author | "Yeoman H."xsd:string |
| http://purl.uniprot.org/citations/1540549 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1540549 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/1540549 | http://purl.uniprot.org/core/pages | "59-65"xsd:string |
| http://purl.uniprot.org/citations/1540549 | http://purl.uniprot.org/core/title | "Tolerance and MHC restriction in transgenic mice expressing a MHC class I gene in erythroid cells."xsd:string |
| http://purl.uniprot.org/citations/1540549 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/1540549 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1540549 |
| http://purl.uniprot.org/citations/1540549 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1540549 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1G3-mappedCitation-1540549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1540549 |
| http://purl.uniprot.org/uniprot/#_K7WBQ4-mappedCitation-1540549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1540549 |
| http://purl.uniprot.org/uniprot/#_A0A482CGP7-mappedCitation-1540549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1540549 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G2-mappedCitation-1540549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1540549 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G8-mappedCitation-1540549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1540549 |
| http://purl.uniprot.org/uniprot/#_A0A494BA33-mappedCitation-1540549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1540549 |
| http://purl.uniprot.org/uniprot/#_A0A494BAT0-mappedCitation-1540549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1540549 |
| http://purl.uniprot.org/uniprot/#_O19449-mappedCitation-1540549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1540549 |
| http://purl.uniprot.org/uniprot/#_G3UXW2-mappedCitation-1540549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1540549 |
| http://purl.uniprot.org/uniprot/#_P04223-mappedCitation-1540549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1540549 |
| http://purl.uniprot.org/uniprot/#_Q31141-mappedCitation-1540549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1540549 |
| http://purl.uniprot.org/uniprot/#_Q31142-mappedCitation-1540549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1540549 |
| http://purl.uniprot.org/uniprot/#_Q31148-mappedCitation-1540549 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1540549 |