| http://purl.uniprot.org/citations/1541278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1541278 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1541278 | http://www.w3.org/2000/01/rdf-schema#comment | "Two cytochrome P450 isozymes, FA and FI, were isolated and characterized from liver microsomes of phenobarbital-induced baboons (Papio papio). The cytochrome FA possesses the same N-terminal amino acid sequence as P450 MK2 from crab-eating monkeys (Macaca irus) and closely resembles the human P450 3A isozymes. This cytochrome was able to oxidize nifedipine and hydroxylate testosterone at the 6 beta position. The second baboon cytochrome (FI) is closely related to the P450 2A subfamily and has the same N-terminal sequence as human P450 2A7. Like human P450 2A forms, it is highly active as a coumarin 7-hydroxylase. Antibodies against P450 FA and FI cross-react with two human liver proteins of 51 kDa and 49 kDa, respectively. The concentration of the first protein in the human samples, was five-times greater than the second. However, the latter showed marked interindividual variation. In primary cultures of human hepatocytes, rifampicin is a strong inducer of the 51-kDa protein and a moderate inducer of the 49-kDa protein, while phenobarbital has the opposite effect on the two proteins."xsd:string |
| http://purl.uniprot.org/citations/1541278 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1432-1033.1992.tb16677.x"xsd:string |
| http://purl.uniprot.org/citations/1541278 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1432-1033.1992.tb16677.x"xsd:string |
| http://purl.uniprot.org/citations/1541278 | http://purl.uniprot.org/core/author | "Fabre G."xsd:string |
| http://purl.uniprot.org/citations/1541278 | http://purl.uniprot.org/core/author | "Fabre G."xsd:string |
| http://purl.uniprot.org/citations/1541278 | http://purl.uniprot.org/core/author | "Bonfils C."xsd:string |
| http://purl.uniprot.org/citations/1541278 | http://purl.uniprot.org/core/author | "Bonfils C."xsd:string |
| http://purl.uniprot.org/citations/1541278 | http://purl.uniprot.org/core/author | "Maurel P."xsd:string |
| http://purl.uniprot.org/citations/1541278 | http://purl.uniprot.org/core/author | "Maurel P."xsd:string |
| http://purl.uniprot.org/citations/1541278 | http://purl.uniprot.org/core/author | "Boulenc X."xsd:string |
| http://purl.uniprot.org/citations/1541278 | http://purl.uniprot.org/core/author | "Boulenc X."xsd:string |
| http://purl.uniprot.org/citations/1541278 | http://purl.uniprot.org/core/author | "Dalet-Beluche I."xsd:string |
| http://purl.uniprot.org/citations/1541278 | http://purl.uniprot.org/core/author | "Dalet-Beluche I."xsd:string |
| http://purl.uniprot.org/citations/1541278 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1541278 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1541278 | http://purl.uniprot.org/core/name | "Eur. J. Biochem."xsd:string |
| http://purl.uniprot.org/citations/1541278 | http://purl.uniprot.org/core/name | "Eur. J. Biochem."xsd:string |
| http://purl.uniprot.org/citations/1541278 | http://purl.uniprot.org/core/pages | "641-648"xsd:string |
| http://purl.uniprot.org/citations/1541278 | http://purl.uniprot.org/core/pages | "641-648"xsd:string |
| http://purl.uniprot.org/citations/1541278 | http://purl.uniprot.org/core/title | "Purification of two cytochrome P450 isozymes related to CYP2A and CYP3A gene families from monkey (baboon, Papio papio) liver microsomes. Cross reactivity with human forms."xsd:string |
| http://purl.uniprot.org/citations/1541278 | http://purl.uniprot.org/core/title | "Purification of two cytochrome P450 isozymes related to CYP2A and CYP3A gene families from monkey (baboon, Papio papio) liver microsomes. Cross reactivity with human forms."xsd:string |
| http://purl.uniprot.org/citations/1541278 | http://purl.uniprot.org/core/volume | "204"xsd:string |
| http://purl.uniprot.org/citations/1541278 | http://purl.uniprot.org/core/volume | "204"xsd:string |