| http://purl.uniprot.org/citations/15450924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15450924 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15450924 | http://www.w3.org/2000/01/rdf-schema#comment | "Two lethal factors (named plancitoxins I and II for major and minor toxins, respectively) with the same LD50 (i.v. injection into mice) of 140 microg/kg were purified from spines of the crown-of-thorns starfish Acanthaster planci. Injection of a sublethal dose of plancitoxin I or II into mice remarkably elevated serum levels of glutamic oxaloacetic transaminase and glutamic pyruvic transaminase, demonstrating that both toxins are potently hepatotoxic. Analysis by SDS-PAGE revealed that both plancitoxins are composed of two subunits (alpha-subunit of 10 kDa and beta-subunit of 27 kDa) bridged by a disulfide bond. Based on the determined N-terminal amino acid sequences of alpha- and beta-subunits, the full-length cDNA (1820 bp) encoding plancitoxin I was cloned by RT-PCR, 3'-RACE and 5'-RACE. alpha-Subunit (92 amino acid residues) and beta-subunit (240 residues) are coded in this order by the same cDNA. Interestingly, the deduced amino acid sequence of plancitoxin I showed 40-42% homologies with mammalian deoxyribonucleases II (DNases II). In addition, plancitoxin I exhibited DNA degrading activity with an optimum pH of 7.2. Plancitoxin I is the first example of toxic DNases II whose structures have been elucidated."xsd:string |
| http://purl.uniprot.org/citations/15450924 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.toxicon.2004.06.012"xsd:string |
| http://purl.uniprot.org/citations/15450924 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.toxicon.2004.06.012"xsd:string |
| http://purl.uniprot.org/citations/15450924 | http://purl.uniprot.org/core/author | "Ishida M."xsd:string |
| http://purl.uniprot.org/citations/15450924 | http://purl.uniprot.org/core/author | "Ishida M."xsd:string |
| http://purl.uniprot.org/citations/15450924 | http://purl.uniprot.org/core/author | "Nagashima Y."xsd:string |
| http://purl.uniprot.org/citations/15450924 | http://purl.uniprot.org/core/author | "Nagashima Y."xsd:string |
| http://purl.uniprot.org/citations/15450924 | http://purl.uniprot.org/core/author | "Shiomi K."xsd:string |
| http://purl.uniprot.org/citations/15450924 | http://purl.uniprot.org/core/author | "Shiomi K."xsd:string |
| http://purl.uniprot.org/citations/15450924 | http://purl.uniprot.org/core/author | "Nagai H."xsd:string |
| http://purl.uniprot.org/citations/15450924 | http://purl.uniprot.org/core/author | "Nagai H."xsd:string |
| http://purl.uniprot.org/citations/15450924 | http://purl.uniprot.org/core/author | "Midorikawa S."xsd:string |
| http://purl.uniprot.org/citations/15450924 | http://purl.uniprot.org/core/author | "Midorikawa S."xsd:string |
| http://purl.uniprot.org/citations/15450924 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15450924 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15450924 | http://purl.uniprot.org/core/name | "Toxicon"xsd:string |
| http://purl.uniprot.org/citations/15450924 | http://purl.uniprot.org/core/name | "Toxicon"xsd:string |
| http://purl.uniprot.org/citations/15450924 | http://purl.uniprot.org/core/pages | "499-506"xsd:string |
| http://purl.uniprot.org/citations/15450924 | http://purl.uniprot.org/core/pages | "499-506"xsd:string |
| http://purl.uniprot.org/citations/15450924 | http://purl.uniprot.org/core/title | "Plancitoxins, lethal factors from the crown-of-thorns starfish Acanthaster planci, are deoxyribonucleases II."xsd:string |
| http://purl.uniprot.org/citations/15450924 | http://purl.uniprot.org/core/title | "Plancitoxins, lethal factors from the crown-of-thorns starfish Acanthaster planci, are deoxyribonucleases II."xsd:string |
| http://purl.uniprot.org/citations/15450924 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/15450924 | http://purl.uniprot.org/core/volume | "44"xsd:string |