| http://purl.uniprot.org/citations/15454081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15454081 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15454081 | http://www.w3.org/2000/01/rdf-schema#comment | "Elevations in circulating glucose and gut hormones during feeding promote pancreatic islet cell viability in part via the calcium- and cAMP-dependent activation of the transcription factor CREB. Here, we describe a signaling module that mediates the synergistic effects of these pathways on cellular gene expression by stimulating the dephosphorylation and nuclear entry of TORC2, a CREB coactivator. This module consists of the calcium-regulated phosphatase calcineurin and the Ser/Thr kinase SIK2, both of which associate with TORC2. Under resting conditions, TORC2 is sequestered in the cytoplasm via a phosphorylation-dependent interaction with 14-3-3 proteins. Triggering of the calcium and cAMP second messenger pathways by glucose and gut hormones disrupts TORC2:14-3-3 complexes via complementary effects on TORC2 dephosphorylation; calcium influx increases calcineurin activity, whereas cAMP inhibits SIK2 kinase activity. Our results illustrate how a phosphatase/kinase module connects two signaling pathways in response to nutrient and hormonal cues."xsd:string |
| http://purl.uniprot.org/citations/15454081 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2004.09.015"xsd:string |
| http://purl.uniprot.org/citations/15454081 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2004.09.015"xsd:string |
| http://purl.uniprot.org/citations/15454081 | http://purl.uniprot.org/core/author | "Best J.L."xsd:string |
| http://purl.uniprot.org/citations/15454081 | http://purl.uniprot.org/core/author | "Best J.L."xsd:string |
| http://purl.uniprot.org/citations/15454081 | http://purl.uniprot.org/core/author | "Canettieri G."xsd:string |
| http://purl.uniprot.org/citations/15454081 | http://purl.uniprot.org/core/author | "Canettieri G."xsd:string |
| http://purl.uniprot.org/citations/15454081 | http://purl.uniprot.org/core/author | "Conkright M.D."xsd:string |
| http://purl.uniprot.org/citations/15454081 | http://purl.uniprot.org/core/author | "Conkright M.D."xsd:string |
| http://purl.uniprot.org/citations/15454081 | http://purl.uniprot.org/core/author | "Guzman E."xsd:string |
| http://purl.uniprot.org/citations/15454081 | http://purl.uniprot.org/core/author | "Guzman E."xsd:string |
| http://purl.uniprot.org/citations/15454081 | http://purl.uniprot.org/core/author | "Jeffries S."xsd:string |
| http://purl.uniprot.org/citations/15454081 | http://purl.uniprot.org/core/author | "Jeffries S."xsd:string |
| http://purl.uniprot.org/citations/15454081 | http://purl.uniprot.org/core/author | "Katoh Y."xsd:string |
| http://purl.uniprot.org/citations/15454081 | http://purl.uniprot.org/core/author | "Katoh Y."xsd:string |
| http://purl.uniprot.org/citations/15454081 | http://purl.uniprot.org/core/author | "Montminy M."xsd:string |
| http://purl.uniprot.org/citations/15454081 | http://purl.uniprot.org/core/author | "Montminy M."xsd:string |
| http://purl.uniprot.org/citations/15454081 | http://purl.uniprot.org/core/author | "Okamoto M."xsd:string |
| http://purl.uniprot.org/citations/15454081 | http://purl.uniprot.org/core/author | "Okamoto M."xsd:string |
| http://purl.uniprot.org/citations/15454081 | http://purl.uniprot.org/core/author | "Niessen S."xsd:string |
| http://purl.uniprot.org/citations/15454081 | http://purl.uniprot.org/core/author | "Niessen S."xsd:string |
| http://purl.uniprot.org/citations/15454081 | http://purl.uniprot.org/core/author | "Yates J.R. III"xsd:string |
| http://purl.uniprot.org/citations/15454081 | http://purl.uniprot.org/core/author | "Yates J.R. III"xsd:string |