| http://purl.uniprot.org/citations/15454086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15454086 | http://www.w3.org/2000/01/rdf-schema#comment | "PGC-1alpha is a coactivator of nuclear receptors and other transcription factors that regulates several metabolic processes, including mitochondrial biogenesis and respiration, hepatic gluconeogenesis, and muscle fiber-type switching. We show here that, while hepatocytes lacking PGC-1alpha are defective in the program of hormone-stimulated gluconeogenesis, the mice have constitutively activated gluconeogenic gene expression that is completely insensitive to normal feeding controls. C/EBPbeta is elevated in the livers of these mice and activates the gluconeogenic genes in a PGC-1alpha-independent manner. Despite having reduced mitochondrial function, PGC-1alpha null mice are paradoxically lean and resistant to diet-induced obesity. This is largely due to a profound hyperactivity displayed by the null animals and is associated with lesions in the striatal region of the brain that controls movement. These data illustrate a central role for PGC-1alpha in the control of energy metabolism but also reveal novel systemic compensatory mechanisms and pathogenic effects of impaired energy homeostasis."xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2004.09.013"xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.uniprot.org/core/author | "Cui L."xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.uniprot.org/core/author | "Lin J."xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.uniprot.org/core/author | "Wu Z."xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.uniprot.org/core/author | "Lowell B.B."xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.uniprot.org/core/author | "Mootha V.K."xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.uniprot.org/core/author | "Jager S."xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.uniprot.org/core/author | "Spiegelman B.M."xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.uniprot.org/core/author | "St-Pierre J."xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.uniprot.org/core/author | "Tarr P.T."xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.uniprot.org/core/author | "Krainc D."xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.uniprot.org/core/author | "Shulman G.I."xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.uniprot.org/core/author | "Zavacki A.M."xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.uniprot.org/core/author | "Zhang C.Y."xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.uniprot.org/core/author | "Cinti S."xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.uniprot.org/core/author | "Vianna C.R."xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.uniprot.org/core/author | "Cooper M.P."xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.uniprot.org/core/author | "Rohas L.M."xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.uniprot.org/core/author | "Wu P.H."xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.uniprot.org/core/author | "Fan M.C."xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.uniprot.org/core/author | "Lindenberg K.S."xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.uniprot.org/core/author | "Manieri M."xsd:string |
| http://purl.uniprot.org/citations/15454086 | http://purl.uniprot.org/core/author | "Donovan M.X."xsd:string |