| http://purl.uniprot.org/citations/15454534 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15454534 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15454534 | http://www.w3.org/2000/01/rdf-schema#comment | "Germ cells can divide mitotically to replenish germline tissue or meiotically to produce gametes. In this article, we report that GLD-3, a Caenorhabditis elegans Bicaudal-C homolog, promotes the transition from mitosis to meiosis together with the GLD-2 poly(A) polymerase. GLD-3 binds GLD-2 via a small N-terminal region present in both GLD-3S and GLD-3L isoforms, and GLD-2 and GLD-3 can be co-immunoprecipitated from worm extracts. The FBF repressor binds specifically to elements in the gld-3S 3'-UTR, and FBF regulates gld-3 expression. Furthermore, FBF acts largely upstream of gld-3 in the mitosis/meiosis decision. By contrast, GLD-3 acts upstream of FBF in the sperm/oocyte decision, and GLD-3 protein can antagonize FBF binding to RNA regulatory elements. To address the relative importance of these two regulatory mechanisms in the mitosis/meiosis and sperm/oocyte decisions, we isolated a deletion mutant, gld-3(q741), that removes the FBF-binding site from GLD-3L, but leaves the GLD-2-binding site intact. Animals homozygous for gld-3(q741) enter meiosis, but are feminized. Therefore, GLD-3 promotes meiosis primarily via its interaction with GLD-2, and it promotes spermatogenesis primarily via its interaction with FBF."xsd:string |
| http://purl.uniprot.org/citations/15454534 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.104.029264"xsd:string |
| http://purl.uniprot.org/citations/15454534 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.104.029264"xsd:string |
| http://purl.uniprot.org/citations/15454534 | http://purl.uniprot.org/core/author | "Kimble J."xsd:string |
| http://purl.uniprot.org/citations/15454534 | http://purl.uniprot.org/core/author | "Kimble J."xsd:string |
| http://purl.uniprot.org/citations/15454534 | http://purl.uniprot.org/core/author | "Eckmann C.R."xsd:string |
| http://purl.uniprot.org/citations/15454534 | http://purl.uniprot.org/core/author | "Eckmann C.R."xsd:string |
| http://purl.uniprot.org/citations/15454534 | http://purl.uniprot.org/core/author | "Crittenden S.L."xsd:string |
| http://purl.uniprot.org/citations/15454534 | http://purl.uniprot.org/core/author | "Crittenden S.L."xsd:string |
| http://purl.uniprot.org/citations/15454534 | http://purl.uniprot.org/core/author | "Suh N."xsd:string |
| http://purl.uniprot.org/citations/15454534 | http://purl.uniprot.org/core/author | "Suh N."xsd:string |
| http://purl.uniprot.org/citations/15454534 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15454534 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15454534 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/15454534 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/15454534 | http://purl.uniprot.org/core/pages | "147-160"xsd:string |
| http://purl.uniprot.org/citations/15454534 | http://purl.uniprot.org/core/pages | "147-160"xsd:string |
| http://purl.uniprot.org/citations/15454534 | http://purl.uniprot.org/core/title | "GLD-3 and control of the mitosis/meiosis decision in the germline of Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/15454534 | http://purl.uniprot.org/core/title | "GLD-3 and control of the mitosis/meiosis decision in the germline of Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/15454534 | http://purl.uniprot.org/core/volume | "168"xsd:string |
| http://purl.uniprot.org/citations/15454534 | http://purl.uniprot.org/core/volume | "168"xsd:string |
| http://purl.uniprot.org/citations/15454534 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15454534 |
| http://purl.uniprot.org/citations/15454534 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15454534 |