| http://purl.uniprot.org/citations/15454540 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15454540 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclin E together with its kinase partner Cdk2 is a critical regulator of entry into S phase. To identify novel genes that regulate the G1-to S-phase transition within a whole animal we made use of a hypomorphic cyclin E mutation, DmcycEJP, which results in a rough eye phenotype. We screened the X and third chromosome deficiencies, tested candidate genes, and carried out a genetic screen of 55,000 EMS or X-ray-mutagenized flies for second or third chromosome mutations that dominantly modified the DmcycEJP rough eye phenotype. We have focused on the DmcycEJP suppressors, S(DmcycEJP), to identify novel negative regulators of S-phase entry. There are 18 suppressor gene groups with more than one allele and several genes that are represented by only a single allele. All S(DmcycEJP) tested suppress the DmcycEJP rough eye phenotype by increasing the number of S phases in the postmorphogenetic furrow S-phase band. By testing candidates we have identified several modifier genes from the mutagenic screen as well as from the deficiency screen. DmcycEJP suppressor genes fall into the classes of: (1) chromatin remodeling or transcription factors; (2) signaling pathways; and (3) cytoskeletal, (4) cell adhesion, and (5) cytoarchitectural tumor suppressors. The cytoarchitectural tumor suppressors include scribble, lethal-2-giant-larvae (lgl), and discs-large (dlg), loss of function of which leads to neoplastic tumors and disruption of apical-basal cell polarity. We further explored the genetic interactions of scribble with S(DmcycEJP) genes and show that hypomorphic scribble mutants exhibit genetic interactions with lgl, scab (alphaPS3-integrin--cell adhesion), phyllopod (signaling), dEB1 (microtubule-binding protein--cytoskeletal), and moira (chromatin remodeling). These interactions of the cytoarchitectural suppressor gene, scribble, with cell adhesion, signaling, cytoskeletal, and chromatin remodeling genes, suggest that these genes may act in a common pathway to negatively regulate cyclin E or S-phase entry."xsd:string |
| http://purl.uniprot.org/citations/15454540 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.104.026617"xsd:string |
| http://purl.uniprot.org/citations/15454540 | http://purl.uniprot.org/core/author | "Richardson H."xsd:string |
| http://purl.uniprot.org/citations/15454540 | http://purl.uniprot.org/core/author | "Amin N."xsd:string |
| http://purl.uniprot.org/citations/15454540 | http://purl.uniprot.org/core/author | "Coates D."xsd:string |
| http://purl.uniprot.org/citations/15454540 | http://purl.uniprot.org/core/author | "Saint R."xsd:string |
| http://purl.uniprot.org/citations/15454540 | http://purl.uniprot.org/core/author | "Secombe J."xsd:string |
| http://purl.uniprot.org/citations/15454540 | http://purl.uniprot.org/core/author | "Coombe M."xsd:string |
| http://purl.uniprot.org/citations/15454540 | http://purl.uniprot.org/core/author | "Brumby A."xsd:string |
| http://purl.uniprot.org/citations/15454540 | http://purl.uniprot.org/core/author | "Horsfield J."xsd:string |
| http://purl.uniprot.org/citations/15454540 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15454540 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/15454540 | http://purl.uniprot.org/core/pages | "227-251"xsd:string |
| http://purl.uniprot.org/citations/15454540 | http://purl.uniprot.org/core/title | "A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/15454540 | http://purl.uniprot.org/core/volume | "168"xsd:string |
| http://purl.uniprot.org/citations/15454540 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15454540 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4KHS1-mappedCitation-15454540 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15454540 |