| http://purl.uniprot.org/citations/15455355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15455355 | http://www.w3.org/2000/01/rdf-schema#comment | "Downregulation of MHC class I expression is a widespread phenomenon used by tumor cells to escape antitumor T-cell-mediated immune responses. These alterations may play a role in the clinical course of the disease. The aim of our study was to investigate the molecular mechanism underlying the absence of HLA-class I molecule expression in bladder cancer cells. Microdissected tumor tissues were characterized by real-time quantitative PCR for the expression of HLA-ABC, beta2-microglobulin and the members of the antigen processing machinery (APM) of HLA class I molecules (LMP2, LMP7, TAP1, TAP2 and tapasin). Our results showed that irreversible HLA loss by mutations in the beta2-microglobulin gene was not the cause of low HLA class I expression in bladder cancers. In contrast, we observed a coordinated transcription downregulation of HLA-ABC and beta2-microglobulin and APM genes in microdissected tumor tissue derived from bladder carcinomas. This mechanism may represent a major factor for the downregulation of HLA class I expression and in the subsequent direct recognition of cancer cells by cytolytic T lymphocytes. Because this regulatory mechanism is frequently reversible by IFN-gamma treatment, we conclude that HLA class I expression should be a major consideration for immunotherapeutic purposes in patients with bladder cancer."xsd:string |
| http://purl.uniprot.org/citations/15455355 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.20499"xsd:string |
| http://purl.uniprot.org/citations/15455355 | http://purl.uniprot.org/core/author | "Ruiz-Cabello F."xsd:string |
| http://purl.uniprot.org/citations/15455355 | http://purl.uniprot.org/core/author | "Jimenez P."xsd:string |
| http://purl.uniprot.org/citations/15455355 | http://purl.uniprot.org/core/author | "Romero J.M."xsd:string |
| http://purl.uniprot.org/citations/15455355 | http://purl.uniprot.org/core/author | "Garrido F."xsd:string |
| http://purl.uniprot.org/citations/15455355 | http://purl.uniprot.org/core/author | "Pedrinaci S."xsd:string |
| http://purl.uniprot.org/citations/15455355 | http://purl.uniprot.org/core/author | "Cabrera T."xsd:string |
| http://purl.uniprot.org/citations/15455355 | http://purl.uniprot.org/core/author | "Cozar J.M."xsd:string |
| http://purl.uniprot.org/citations/15455355 | http://purl.uniprot.org/core/author | "Tallada M."xsd:string |
| http://purl.uniprot.org/citations/15455355 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15455355 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/15455355 | http://purl.uniprot.org/core/pages | "605-610"xsd:string |
| http://purl.uniprot.org/citations/15455355 | http://purl.uniprot.org/core/title | "Coordinated downregulation of the antigen presentation machinery and HLA class I/beta2-microglobulin complex is responsible for HLA-ABC loss in bladder cancer."xsd:string |
| http://purl.uniprot.org/citations/15455355 | http://purl.uniprot.org/core/volume | "113"xsd:string |
| http://purl.uniprot.org/citations/15455355 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15455355 |
| http://purl.uniprot.org/citations/15455355 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15455355 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-15455355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15455355 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-15455355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15455355 |
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| http://purl.uniprot.org/uniprot/#_A0A0G2R0N5-mappedCitation-15455355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15455355 |
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| http://purl.uniprot.org/uniprot/#_A0A076L0P9-mappedCitation-15455355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15455355 |