| http://purl.uniprot.org/citations/15456725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15456725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15456725 | http://www.w3.org/2000/01/rdf-schema#comment | "The nervous system in many species consists of multiple neuronal cell layers, each forming specific connections with neurons in other layers or other regions of the brain. How layer-specific connectivity is established during development remains largely unknown. In the Drosophila adult visual system, photoreceptor (R cell) axons innervate one of two optic ganglia layers; R1-R6 axons connect to the lamina layer, while R7 and R8 axons project through the lamina into the deeper medulla layer. Here, we show that the receptor tyrosine kinase Off-track (Otk) is specifically required for lamina-specific targeting of R1-R6 axons. Otk is highly expressed on R1-R6 growth cones. In the absence of otk, many R1-R6 axons connect abnormally to medulla instead of innervating lamina. We propose that Otk is a receptor or a component of a receptor complex that recognizes a target-derived signal for R1-R6 axons to innervate the lamina layer."xsd:string |
| http://purl.uniprot.org/citations/15456725 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.01406"xsd:string |
| http://purl.uniprot.org/citations/15456725 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.01406"xsd:string |
| http://purl.uniprot.org/citations/15456725 | http://purl.uniprot.org/core/author | "Yu L."xsd:string |
| http://purl.uniprot.org/citations/15456725 | http://purl.uniprot.org/core/author | "Yu L."xsd:string |
| http://purl.uniprot.org/citations/15456725 | http://purl.uniprot.org/core/author | "Rao Y."xsd:string |
| http://purl.uniprot.org/citations/15456725 | http://purl.uniprot.org/core/author | "Rao Y."xsd:string |
| http://purl.uniprot.org/citations/15456725 | http://purl.uniprot.org/core/author | "Cafferty P."xsd:string |
| http://purl.uniprot.org/citations/15456725 | http://purl.uniprot.org/core/author | "Cafferty P."xsd:string |
| http://purl.uniprot.org/citations/15456725 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15456725 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15456725 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/15456725 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/15456725 | http://purl.uniprot.org/core/pages | "5287-5295"xsd:string |
| http://purl.uniprot.org/citations/15456725 | http://purl.uniprot.org/core/pages | "5287-5295"xsd:string |
| http://purl.uniprot.org/citations/15456725 | http://purl.uniprot.org/core/title | "The receptor tyrosine kinase Off-track is required for layer-specific neuronal connectivity in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/15456725 | http://purl.uniprot.org/core/title | "The receptor tyrosine kinase Off-track is required for layer-specific neuronal connectivity in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/15456725 | http://purl.uniprot.org/core/volume | "131"xsd:string |
| http://purl.uniprot.org/citations/15456725 | http://purl.uniprot.org/core/volume | "131"xsd:string |
| http://purl.uniprot.org/citations/15456725 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15456725 |
| http://purl.uniprot.org/citations/15456725 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15456725 |
| http://purl.uniprot.org/citations/15456725 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15456725 |
| http://purl.uniprot.org/citations/15456725 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15456725 |