| http://purl.uniprot.org/citations/15456882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15456882 | http://www.w3.org/2000/01/rdf-schema#comment | "The regulation of cytokine signaling is critical for controlling cellular proliferation and activation during an immune response. SOCS-1 is a potent inhibitor of Jak kinase activity and of signaling initiated by several cytokines. SOCS-1 protein levels are tightly regulated, and recent data suggest that SOCS-1 may regulate the protein levels of some signaling proteins by the ubiquitin proteasome pathway; however, the cellular mechanism by which SOCS-1 directs proteins for degradation is unknown. In this report, SOCS-1 is found to colocalize and biochemically copurify with the microtubule organizing complex (MTOC) and its associated 20S proteasome. The SOCS-1 SH2 domain is required for the localization of SOCS-1 to the MTOC. Overexpression of SOCS-1 targets Jak1 in an SH2-dependent manner to a perinuclear distribution resembling the MTOC-associated 20S proteasome. Analysis of MTOCs fractionated from SOCS-1-deficient cells demonstrates that SOCS-1 may function redundantly to regulate the localization of Jak1 to the MTOC. Nocodazole inhibits the protein turnover of SOCS-1, demonstrating that the minus-end transport of SOCS-1 to the MTOC-associated 20S proteasome is required to regulate SOCS-1 protein levels. These data link SOCS-1 directly with the proteasome pathway and suggest another function for the SH2 domain of SOCS-1 in the regulation of Jak/STAT signaling."xsd:string |
| http://purl.uniprot.org/citations/15456882 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.24.20.9092-9101.2004"xsd:string |
| http://purl.uniprot.org/citations/15456882 | http://purl.uniprot.org/core/author | "Vuong B.Q."xsd:string |
| http://purl.uniprot.org/citations/15456882 | http://purl.uniprot.org/core/author | "Chen X.P."xsd:string |
| http://purl.uniprot.org/citations/15456882 | http://purl.uniprot.org/core/author | "Rothman P.B."xsd:string |
| http://purl.uniprot.org/citations/15456882 | http://purl.uniprot.org/core/author | "Banks A.S."xsd:string |
| http://purl.uniprot.org/citations/15456882 | http://purl.uniprot.org/core/author | "Limnander A."xsd:string |
| http://purl.uniprot.org/citations/15456882 | http://purl.uniprot.org/core/author | "Losman J."xsd:string |
| http://purl.uniprot.org/citations/15456882 | http://purl.uniprot.org/core/author | "Fernandez N."xsd:string |
| http://purl.uniprot.org/citations/15456882 | http://purl.uniprot.org/core/author | "Arenzana T.L."xsd:string |
| http://purl.uniprot.org/citations/15456882 | http://purl.uniprot.org/core/author | "Mostecki J."xsd:string |
| http://purl.uniprot.org/citations/15456882 | http://purl.uniprot.org/core/author | "Showalter B.M."xsd:string |
| http://purl.uniprot.org/citations/15456882 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15456882 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/15456882 | http://purl.uniprot.org/core/pages | "9092-9101"xsd:string |
| http://purl.uniprot.org/citations/15456882 | http://purl.uniprot.org/core/title | "SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome."xsd:string |
| http://purl.uniprot.org/citations/15456882 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/15456882 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15456882 |
| http://purl.uniprot.org/citations/15456882 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15456882 |
| http://purl.uniprot.org/uniprot/#_E0CYT5-mappedCitation-15456882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15456882 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EBZ1-mappedCitation-15456882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15456882 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BQ49-mappedCitation-15456882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15456882 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BQ79-mappedCitation-15456882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15456882 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EI83-mappedCitation-15456882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15456882 |