DESCRIBE <http://purl.uniprot.org/citations/15457580>

Subject	Predicate	Object
http://purl.uniprot.org/citations/15457580	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15457580	http://www.w3.org/2000/01/rdf-schema#comment	" Aim To investigate the expression of tumor suppressor gene p27 and spindle checkpoint gene Mad2 and to demonstrate their expression difference in colorectal cancer and normal mucosa and to evaluate its clinical significance. Methods Immunohistochemical staining was used for detection of expression of Mad2 and p27 in colorectal cancer and its corresponding normal mucosa. Results Mad2 was significantly overexpressed in colorectal cancer compared with corresponding normal mucosa (P<0.01, chi(2) = 7.5), and it was related to the differentiation of adenocarcinoma, lymph node metastasis and survival period after excision (P<0.05, chi(2) = 7.72, chi(2) = 4.302, chi(2) = 6.234). The rate of p27 positive expression in adenocarcinomas and normal mucosa was 40% and 80% respectively. There was a significant difference in p27 expression between adenocarcinomas and normal mucosa (P<0.001, chi(2) = 13.333), which was related to the differentiation degree of adenoca rcinoma and lymph node metastasis (P<0.05, chi(2) = 8.901 chi(2) = 4). The positive expression of p27 was not correlated with survival period after excision. Conclusion Defect of spindle checkpoint gene Mad2 and mutation of p27 gene are involved mainly in colorectal carcinogenesis and associated with prognosis of colorectal cancer."xsd:string
http://purl.uniprot.org/citations/15457580	http://purl.org/dc/terms/identifier	"doi:10.3748/wjg.v10.i21.3218"xsd:string
http://purl.uniprot.org/citations/15457580	http://purl.uniprot.org/core/author	"Li G.Q."xsd:string
http://purl.uniprot.org/citations/15457580	http://purl.uniprot.org/core/author	"Zhang H.F."xsd:string
http://purl.uniprot.org/citations/15457580	http://purl.uniprot.org/core/date	"2004"xsd:gYear
http://purl.uniprot.org/citations/15457580	http://purl.uniprot.org/core/name	"World J Gastroenterol"xsd:string
http://purl.uniprot.org/citations/15457580	http://purl.uniprot.org/core/pages	"3218-3220"xsd:string
http://purl.uniprot.org/citations/15457580	http://purl.uniprot.org/core/title	"Mad2 and p27 expression profiles in colorectal cancer and its clinical significance."xsd:string
http://purl.uniprot.org/citations/15457580	http://purl.uniprot.org/core/volume	"10"xsd:string
http://purl.uniprot.org/citations/15457580	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/15457580
http://purl.uniprot.org/citations/15457580	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/15457580
http://purl.uniprot.org/uniprot/#_A7KMP4-mappedCitation-15457580	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/15457580
http://purl.uniprot.org/uniprot/#_B4DPH2-mappedCitation-15457580	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/15457580
http://purl.uniprot.org/uniprot/#_Q13257-mappedCitation-15457580	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/15457580
http://purl.uniprot.org/uniprot/#_O43806-mappedCitation-15457580	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/15457580
http://purl.uniprot.org/uniprot/#_P46527-mappedCitation-15457580	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/15457580
http://purl.uniprot.org/uniprot/#_Q708J1-mappedCitation-15457580	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/15457580
http://purl.uniprot.org/uniprot/#_Q6I9V6-mappedCitation-15457580	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/15457580
http://purl.uniprot.org/uniprot/#_Q96TE0-mappedCitation-15457580	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/15457580
http://purl.uniprot.org/uniprot/#_Q9NYG6-mappedCitation-15457580	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/15457580
http://purl.uniprot.org/uniprot/#_Q9UH60-mappedCitation-15457580	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/15457580
http://purl.uniprot.org/uniprot/#_Q9UQA3-mappedCitation-15457580	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/15457580
http://purl.uniprot.org/uniprot/Q9UH60	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/15457580
http://purl.uniprot.org/uniprot/B4DPH2	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/15457580