| http://purl.uniprot.org/citations/15458638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15458638 | http://www.w3.org/2000/01/rdf-schema#comment | "The bacterial heat shock protein Hsp33 is a redox-regulated chaperone activated by oxidative stress. In response to oxidation, four cysteines within a Zn2+ binding C-terminal domain form two disulfide bonds with concomitant release of the metal. This leads to the formation of the biologically active Hsp33 dimer. The crystal structure of the N-terminal domain of the E. coli protein has been reported, but neither the structure of the Zn2+ binding motif nor the nature of its regulatory interaction with the rest of the protein are known. Here we report the crystal structure of the full-length B. subtilis Hsp33 in the reduced form. The structure of the N-terminal, dimerization domain is similar to that of the E. coli protein, although there is no domain swapping. The Zn2+ binding domain is clearly resolved showing the details of the tetrahedral coordination of Zn2+ by four thiolates. We propose a structure-based activation pathway for Hsp33."xsd:string |
| http://purl.uniprot.org/citations/15458638 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2004.08.003"xsd:string |
| http://purl.uniprot.org/citations/15458638 | http://purl.uniprot.org/core/author | "Dauter Z."xsd:string |
| http://purl.uniprot.org/citations/15458638 | http://purl.uniprot.org/core/author | "Joachimiak A."xsd:string |
| http://purl.uniprot.org/citations/15458638 | http://purl.uniprot.org/core/author | "Cooper D.R."xsd:string |
| http://purl.uniprot.org/citations/15458638 | http://purl.uniprot.org/core/author | "Derewenda U."xsd:string |
| http://purl.uniprot.org/citations/15458638 | http://purl.uniprot.org/core/author | "Derewenda Z.S."xsd:string |
| http://purl.uniprot.org/citations/15458638 | http://purl.uniprot.org/core/author | "Devedjiev Y."xsd:string |
| http://purl.uniprot.org/citations/15458638 | http://purl.uniprot.org/core/author | "Jakob U."xsd:string |
| http://purl.uniprot.org/citations/15458638 | http://purl.uniprot.org/core/author | "Janda I."xsd:string |
| http://purl.uniprot.org/citations/15458638 | http://purl.uniprot.org/core/author | "Bielnicki J."xsd:string |
| http://purl.uniprot.org/citations/15458638 | http://purl.uniprot.org/core/author | "Graf P.C."xsd:string |
| http://purl.uniprot.org/citations/15458638 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15458638 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/15458638 | http://purl.uniprot.org/core/pages | "1901-1907"xsd:string |
| http://purl.uniprot.org/citations/15458638 | http://purl.uniprot.org/core/title | "The crystal structure of the reduced, Zn2+-bound form of the B. subtilis Hsp33 chaperone and its implications for the activation mechanism."xsd:string |
| http://purl.uniprot.org/citations/15458638 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/15458638 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15458638 |
| http://purl.uniprot.org/citations/15458638 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15458638 |
| http://purl.uniprot.org/uniprot/#_P37565-mappedCitation-15458638 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15458638 |
| http://purl.uniprot.org/uniprot/P37565 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15458638 |