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http://purl.uniprot.org/citations/15459486http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15459486http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Fatty acid-binding proteins (FABPs) are involved in lipid metabolism by intracellular transport of long-chain fatty acids. Heart-type (H-) FABP has been reported to inhibit cell growth and induce cell differentiation, but to our knowledge the significance of H-FABP expression in human gastric carcinoma has not been elucidated. The aim of the current study was to examine the expression of H-FABP and its relation to clinicopathologic parameters and fatty acid synthase (FAS) status of gastric carcinoma, since gastric cancer shows increased expression of FAS.

Methods

Immunohistochemistry with anti-H-FABP antibody was performed in 669 gastric carcinomas and 60 tubular adenomas of the stomach. H-FABP-positive and H-FABP-negative carcinomas were analyzed for their clinicopathologic characteristics and FAS status.

Results

None of the adenomas expressed H-FABP, whereas 127 of 669 carcinomas (19.0%) were positive for the protein. H-FABP positivity was associated with the depth of invasion (p <0.0001), vascular invasion (p <0.0001), lymph node metastasis (p <0.0001), hepatic metastasis (p=0.0011), stage of the carcinoma (p <0.0001) and FAS status of the carcinoma (p=0.0476). A higher survival rate was noted in H-FABP-negative cases compared with H-FABP-positive cases (p=0.0004).

Conclusions

A subset of human gastric carcinoma expresses H-FABP and its expression is associated with FAS status, disease progression, tumor aggressiveness and poor patient survival."xsd:string
http://purl.uniprot.org/citations/15459486http://purl.org/dc/terms/identifier"doi:10.1159/000080061"xsd:string
http://purl.uniprot.org/citations/15459486http://purl.uniprot.org/core/author"Hashimoto T."xsd:string
http://purl.uniprot.org/citations/15459486http://purl.uniprot.org/core/author"Fukuda T."xsd:string
http://purl.uniprot.org/citations/15459486http://purl.uniprot.org/core/author"Fujii H."xsd:string
http://purl.uniprot.org/citations/15459486http://purl.uniprot.org/core/author"Kimura H."xsd:string
http://purl.uniprot.org/citations/15459486http://purl.uniprot.org/core/author"Suzuki T."xsd:string
http://purl.uniprot.org/citations/15459486http://purl.uniprot.org/core/author"Sato Y."xsd:string
http://purl.uniprot.org/citations/15459486http://purl.uniprot.org/core/author"Watanabe K."xsd:string
http://purl.uniprot.org/citations/15459486http://purl.uniprot.org/core/author"Kusakabe T."xsd:string
http://purl.uniprot.org/citations/15459486http://purl.uniprot.org/core/author"Sugino T."xsd:string
http://purl.uniprot.org/citations/15459486http://purl.uniprot.org/core/author"Honma K."xsd:string
http://purl.uniprot.org/citations/15459486http://purl.uniprot.org/core/author"Nashimoto A."xsd:string
http://purl.uniprot.org/citations/15459486http://purl.uniprot.org/core/date"2004"xsd:gYear
http://purl.uniprot.org/citations/15459486http://purl.uniprot.org/core/name"Pathobiology"xsd:string
http://purl.uniprot.org/citations/15459486http://purl.uniprot.org/core/pages"267-273"xsd:string
http://purl.uniprot.org/citations/15459486http://purl.uniprot.org/core/title"Expression of heart-type fatty acid-binding protein in human gastric carcinoma and its association with tumor aggressiveness, metastasis and poor prognosis."xsd:string
http://purl.uniprot.org/citations/15459486http://purl.uniprot.org/core/volume"71"xsd:string
http://purl.uniprot.org/citations/15459486http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15459486
http://purl.uniprot.org/citations/15459486http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/15459486
http://purl.uniprot.org/uniprot/#_A0A384MDY5-mappedCitation-15459486http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15459486
http://purl.uniprot.org/uniprot/#_P05413-mappedCitation-15459486http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15459486
http://purl.uniprot.org/uniprot/#_Q6IBD7-mappedCitation-15459486http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/15459486
http://purl.uniprot.org/uniprot/A0A384MDY5http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/15459486
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