| http://purl.uniprot.org/citations/15464995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15464995 | http://www.w3.org/2000/01/rdf-schema#comment | "The induction of null mutations by means of homologous recombination is a powerful technique for clarifying the biological activities of target genes. However, the problems of the genetic background and flanking genes should be borne in mind. Here we employed a breeding strategy to compare three lines of mice deficient in the basigin (Bsg)/CD147 gene. The first line was F2 from F1 hybrid offspring of the 129/SV chimera and C57BL/6J. The second one was from a C57BL/6J congenic line. Both lines showed high embryonic lethality, sterility, and blindness. The third one was 'reverse F2' from 'reverse F1' hybrid offspring of the C57BL/6J congenic line and 129/SV. Surprisingly, this line showed a normal birth rate, while sterility and blindness persisted. Our results clearly separate the effects of the induced null mutation from those of flanking genes and the genetic background, and provide a useful means of investigating the biological functions of Bsg."xsd:string |
| http://purl.uniprot.org/citations/15464995 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2004.08.232"xsd:string |
| http://purl.uniprot.org/citations/15464995 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/15464995 | http://purl.uniprot.org/core/author | "Kondo M."xsd:string |
| http://purl.uniprot.org/citations/15464995 | http://purl.uniprot.org/core/author | "Toyama Y."xsd:string |
| http://purl.uniprot.org/citations/15464995 | http://purl.uniprot.org/core/author | "Muramatsu T."xsd:string |
| http://purl.uniprot.org/citations/15464995 | http://purl.uniprot.org/core/author | "Miyake Y."xsd:string |
| http://purl.uniprot.org/citations/15464995 | http://purl.uniprot.org/core/author | "Ueno S."xsd:string |
| http://purl.uniprot.org/citations/15464995 | http://purl.uniprot.org/core/author | "Kadomatsu K."xsd:string |
| http://purl.uniprot.org/citations/15464995 | http://purl.uniprot.org/core/author | "Toshimori K."xsd:string |
| http://purl.uniprot.org/citations/15464995 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15464995 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/15464995 | http://purl.uniprot.org/core/pages | "147-153"xsd:string |
| http://purl.uniprot.org/citations/15464995 | http://purl.uniprot.org/core/title | "Effects of flanking genes on the phenotypes of mice deficient in basigin/CD147."xsd:string |
| http://purl.uniprot.org/citations/15464995 | http://purl.uniprot.org/core/volume | "324"xsd:string |
| http://purl.uniprot.org/citations/15464995 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15464995 |
| http://purl.uniprot.org/citations/15464995 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15464995 |
| http://purl.uniprot.org/uniprot/#_J3QP71-mappedCitation-15464995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15464995 |
| http://purl.uniprot.org/uniprot/#_P18572-mappedCitation-15464995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15464995 |
| http://purl.uniprot.org/uniprot/#_O55107-mappedCitation-15464995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15464995 |
| http://purl.uniprot.org/uniprot/#_O55108-mappedCitation-15464995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15464995 |
| http://purl.uniprot.org/uniprot/#_K3W4Q8-mappedCitation-15464995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15464995 |
| http://purl.uniprot.org/uniprot/P18572 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15464995 |
| http://purl.uniprot.org/uniprot/K3W4Q8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15464995 |