| http://purl.uniprot.org/citations/15466468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15466468 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15466468 | http://www.w3.org/2000/01/rdf-schema#comment | "Tax, a protein encoded by the env-pX gene of human T-cell leukemia virus type I (HTLV-I), interacts with various host cell transcription factors. Tax activates transcription from the long terminal repeat (LTR) of HTLV-I through association with cyclic AMP-responsive element-binding protein (CREB). Here, we present evidence that transducer of regulated cyclic AMP-response element-binding protein 3 (TORC3), a co-activator of CREB, is involved in Tax-induced transcriptional activation from the HTLV-I LTR. By using a luciferase assay system, we show that TORC3 alone can enhance transcription from the HTLV-I LTR, as well as from a cellular cyclic AMP-response element (CRE). Interestingly, we find that co-expression of TORC3 and Tax dramatically increased transcriptional activation at the HTLV-I LTR. We also show by glutathione S-transferase pull-down and co-immunoprecipitation experiments that TORC3 interacts with Tax. Using deletion mutant analysis, we identify the Tax interaction domain of TORC3 as a region spanning from amino acid 1 to 103, which contains a coiled-coil domain. These results provide important clues toward understanding the molecular mechanism of Tax-dependent transcriptional activation of the HTLV-I LTR."xsd:string |
| http://purl.uniprot.org/citations/15466468 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m409021200"xsd:string |
| http://purl.uniprot.org/citations/15466468 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m409021200"xsd:string |
| http://purl.uniprot.org/citations/15466468 | http://purl.uniprot.org/core/author | "Ohshima T."xsd:string |
| http://purl.uniprot.org/citations/15466468 | http://purl.uniprot.org/core/author | "Ohshima T."xsd:string |
| http://purl.uniprot.org/citations/15466468 | http://purl.uniprot.org/core/author | "Koga H."xsd:string |
| http://purl.uniprot.org/citations/15466468 | http://purl.uniprot.org/core/author | "Koga H."xsd:string |
| http://purl.uniprot.org/citations/15466468 | http://purl.uniprot.org/core/author | "Shimotohno K."xsd:string |
| http://purl.uniprot.org/citations/15466468 | http://purl.uniprot.org/core/author | "Shimotohno K."xsd:string |
| http://purl.uniprot.org/citations/15466468 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15466468 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15466468 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15466468 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15466468 | http://purl.uniprot.org/core/pages | "52978-52983"xsd:string |
| http://purl.uniprot.org/citations/15466468 | http://purl.uniprot.org/core/pages | "52978-52983"xsd:string |
| http://purl.uniprot.org/citations/15466468 | http://purl.uniprot.org/core/title | "Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3."xsd:string |
| http://purl.uniprot.org/citations/15466468 | http://purl.uniprot.org/core/title | "Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3."xsd:string |
| http://purl.uniprot.org/citations/15466468 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/15466468 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/15466468 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15466468 |
| http://purl.uniprot.org/citations/15466468 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15466468 |
| http://purl.uniprot.org/citations/15466468 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15466468 |
| http://purl.uniprot.org/citations/15466468 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15466468 |