| http://purl.uniprot.org/citations/15469971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15469971 | http://www.w3.org/2000/01/rdf-schema#comment | "The Ret receptor tyrosine kinase mediates physiological signals of glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) and is essential for postnatal survival in mice. It is implicated in a number of human diseases and developmental abnormalities. Here, we describe our analyses of mice expressing a Ret mutant (RetDN) with diminished kinase activity that inhibits wild-type Ret activity, including its activation of AKT. All RetDN/+ mice died by 1 month of age and had distal intestinal aganglionosis reminiscent of Hirschsprung disease (HSCR) in humans. The RetDN/+ proximal small intestine also had severe hypoganglionosis and reduction in nerve fiber density, suggesting a potential mechanism for the continued gastric dysmotility in postsurgical HSCR patients. Unlike Ret-null mice, which have abnormalities in the parasympathetic and sympathetic nervous systems, the RetDN/+ mice only had defects in the parasympathetic nervous system. A small proportion of RetDN/+ mice had renal agenesis, and the remainder had hypoplastic kidneys and developed tubulocystic abnormalities postnatally. Postnatal analyses of the testes revealed a decreased number of germ cells, degenerating seminiferous tubules, maturation arrest and apoptosis, indicating a crucial role for Ret in early spermatogenesis."xsd:string |
| http://purl.uniprot.org/citations/15469971 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.01421"xsd:string |
| http://purl.uniprot.org/citations/15469971 | http://purl.uniprot.org/core/author | "Jain S."xsd:string |
| http://purl.uniprot.org/citations/15469971 | http://purl.uniprot.org/core/author | "Milbrandt J."xsd:string |
| http://purl.uniprot.org/citations/15469971 | http://purl.uniprot.org/core/author | "Yang M."xsd:string |
| http://purl.uniprot.org/citations/15469971 | http://purl.uniprot.org/core/author | "Gupta A."xsd:string |
| http://purl.uniprot.org/citations/15469971 | http://purl.uniprot.org/core/author | "Johnson E.M. Jr."xsd:string |
| http://purl.uniprot.org/citations/15469971 | http://purl.uniprot.org/core/author | "Strickland A."xsd:string |
| http://purl.uniprot.org/citations/15469971 | http://purl.uniprot.org/core/author | "Golden J."xsd:string |
| http://purl.uniprot.org/citations/15469971 | http://purl.uniprot.org/core/author | "Encinas M."xsd:string |
| http://purl.uniprot.org/citations/15469971 | http://purl.uniprot.org/core/author | "Naughton C.K."xsd:string |
| http://purl.uniprot.org/citations/15469971 | http://purl.uniprot.org/core/author | "Heuckeroth R."xsd:string |
| http://purl.uniprot.org/citations/15469971 | http://purl.uniprot.org/core/author | "Vij K."xsd:string |
| http://purl.uniprot.org/citations/15469971 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15469971 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/15469971 | http://purl.uniprot.org/core/pages | "5503-5513"xsd:string |
| http://purl.uniprot.org/citations/15469971 | http://purl.uniprot.org/core/title | "Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis."xsd:string |
| http://purl.uniprot.org/citations/15469971 | http://purl.uniprot.org/core/volume | "131"xsd:string |
| http://purl.uniprot.org/citations/15469971 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15469971 |
| http://purl.uniprot.org/citations/15469971 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15469971 |
| http://purl.uniprot.org/uniprot/#_F5CNE9-mappedCitation-15469971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15469971 |
| http://purl.uniprot.org/uniprot/#_B4DGX8-mappedCitation-15469971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15469971 |
| http://purl.uniprot.org/uniprot/#_F8TLS5-mappedCitation-15469971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15469971 |
| http://purl.uniprot.org/uniprot/#_F8TLW0-mappedCitation-15469971 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15469971 |