| http://purl.uniprot.org/citations/15471851 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15471851 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15471851 | http://www.w3.org/2000/01/rdf-schema#comment | "p21-activated protein kinase (PAK)-2 is a member of the PAK family of serine/threonine kinases. PAKs are activated by the p21 G-proteins Rac and Cdc42 in response to a variety of extracellular signals and act in pathways controlling cell growth, shape, motility, survival, and death. PAK-2 is unique among the PAK family members because it is also activated through proteolytic cleavage by caspase-3 or similar proteases to generate the constitutively active PAK-2p34 fragment. Activation of full-length PAK-2 by Rac or Cdc42 stimulates cell survival and protects cells from cell death, whereas caspase-activated PAK-2p34 induces a cell death response. Caspase-activated PAK-2p34 is rapidly degraded by the 26 S proteasome, but full-length PAK-2 is not. Stabilization of PAK-2p34 by preventing its polyubiquitination and degradation results in a dramatic stimulation of cell death. Although many proteins have been shown to interact with and regulate full-length PAK-2, little is known about the regulation of caspase-activated PAK-2p34. Here, we identify PS-GAP as a regulator of caspase-activated PAK-2p34. PS-GAP is a GTPase-activating protein for Cdc42 and RhoA that was originally identified by its interaction with the tyrosine kinase PYK-2. PS-GAP interacts specifically with caspase-activated PAK-2p34, but not active or inactive full-length PAK-2, through a region between the GAP and SH3 domains. The interaction with PS-GAP inhibits the protein kinase activity of PAK-2p34 and changes the localization of PAK-2p34 from the nucleus to the perinuclear region. Furthermore, PS-GAP decreases the stimulation of cell death induced by stabilization of PAK-2p34."xsd:string |
| http://purl.uniprot.org/citations/15471851 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m410530200"xsd:string |
| http://purl.uniprot.org/citations/15471851 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m410530200"xsd:string |
| http://purl.uniprot.org/citations/15471851 | http://purl.uniprot.org/core/author | "Jakobi R."xsd:string |
| http://purl.uniprot.org/citations/15471851 | http://purl.uniprot.org/core/author | "Jakobi R."xsd:string |
| http://purl.uniprot.org/citations/15471851 | http://purl.uniprot.org/core/author | "Koeppel M.A."xsd:string |
| http://purl.uniprot.org/citations/15471851 | http://purl.uniprot.org/core/author | "Koeppel M.A."xsd:string |
| http://purl.uniprot.org/citations/15471851 | http://purl.uniprot.org/core/author | "Moertl E."xsd:string |
| http://purl.uniprot.org/citations/15471851 | http://purl.uniprot.org/core/author | "Moertl E."xsd:string |
| http://purl.uniprot.org/citations/15471851 | http://purl.uniprot.org/core/author | "McCarthy C.C."xsd:string |
| http://purl.uniprot.org/citations/15471851 | http://purl.uniprot.org/core/author | "McCarthy C.C."xsd:string |
| http://purl.uniprot.org/citations/15471851 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15471851 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15471851 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15471851 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15471851 | http://purl.uniprot.org/core/pages | "53653-53664"xsd:string |
| http://purl.uniprot.org/citations/15471851 | http://purl.uniprot.org/core/pages | "53653-53664"xsd:string |
| http://purl.uniprot.org/citations/15471851 | http://purl.uniprot.org/core/title | "Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2."xsd:string |
| http://purl.uniprot.org/citations/15471851 | http://purl.uniprot.org/core/title | "Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2."xsd:string |
| http://purl.uniprot.org/citations/15471851 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/15471851 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/15471851 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15471851 |
| http://purl.uniprot.org/citations/15471851 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15471851 |