| http://purl.uniprot.org/citations/15472117 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15472117 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the cardiac myosin binding protein-C gene (cMyBP-C) are among the most prevalent causes of inherited hypertrophic cardiomyopathy. Although most cMyBP-C mutations cause reading frameshifts that are predicted to encode truncated peptides, it is not known if or how expression of these peptides causes disease. One possibility is that because the N-terminus contains a unique binding site for the S2 subfragment of myosin, shortened cMyBP-C peptides could directly affect myosin contraction by binding to S2. To test this hypothesis, we compared the effects of a C1C2 protein containing the myosin S2 binding site on contractile properties in permeabilized myocytes from wild-type and cMyBP-C knockout mice. In wild-type myocytes, the C1C2 protein reversibly increased myofilament Ca2+ sensitivity of tension, but had no effect on resting tension. Identical results were observed in cMyBP-C knockout myocytes where C1C2 increased Ca2+ sensitivity of tension with the half-maximal response elicited at approximately 5 micromol/L C1C2. Maximum force was not affected by C1C2. However, phosphorylation of C1C2 by cAMP-dependent protein kinase reduced its ability to increase Ca2+ sensitivity. These results demonstrate that binding of the C1C2 peptide to S2 alone is sufficient to affect myosin contractile function and suggest that regulated binding of cMyBP-C to myosin S2 by phosphorylation directly influences myofilament Ca2+ sensitivity."xsd:string |
| http://purl.uniprot.org/citations/15472117 | http://purl.org/dc/terms/identifier | "doi:10.1161/01.res.0000147312.02673.56"xsd:string |
| http://purl.uniprot.org/citations/15472117 | http://purl.uniprot.org/core/author | "Gautel M."xsd:string |
| http://purl.uniprot.org/citations/15472117 | http://purl.uniprot.org/core/author | "Moss R.L."xsd:string |
| http://purl.uniprot.org/citations/15472117 | http://purl.uniprot.org/core/author | "Rostkova E."xsd:string |
| http://purl.uniprot.org/citations/15472117 | http://purl.uniprot.org/core/author | "Harris S.P."xsd:string |
| http://purl.uniprot.org/citations/15472117 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15472117 | http://purl.uniprot.org/core/name | "Circ Res"xsd:string |
| http://purl.uniprot.org/citations/15472117 | http://purl.uniprot.org/core/pages | "930-936"xsd:string |
| http://purl.uniprot.org/citations/15472117 | http://purl.uniprot.org/core/title | "Binding of myosin binding protein-C to myosin subfragment S2 affects contractility independent of a tether mechanism."xsd:string |
| http://purl.uniprot.org/citations/15472117 | http://purl.uniprot.org/core/volume | "95"xsd:string |
| http://purl.uniprot.org/citations/15472117 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15472117 |
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