| http://purl.uniprot.org/citations/15472150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15472150 | http://www.w3.org/2000/01/rdf-schema#comment | "A low level of the central antioxidant enzyme catalase has been suggested to be a risk factor for diseases influenced by oxidative stress. In this study, we investigated the possible association of the catalase -262C/T polymorphism with survival, physical and cognitive functioning, and a number of oxidative stress-mediated disorders. The study population was 2223 Danish individuals, aged 45-93 years, drawn from three population-based surveys. The results suggest that the catalase -262C/T polymorphism is not associated with either survival, or the majority of the age-related phenotypes investigated. However, our data indicate a statistical significant association of TT homozygosity with improved physical functioning as well as a trend of the T allele conferring an improved general cognitive functioning, although these results did not remain significant after correcting for multiple testing. The results raise the hypothesis that the catalase -262T allele serves as protection against neurodegenerative and physical decline, although replication in other studies is warranted for confirmation of these findings."xsd:string |
| http://purl.uniprot.org/citations/15472150 | http://purl.org/dc/terms/identifier | "doi:10.1093/gerona/59.9.b886"xsd:string |
| http://purl.uniprot.org/citations/15472150 | http://purl.uniprot.org/core/author | "Christiansen L."xsd:string |
| http://purl.uniprot.org/citations/15472150 | http://purl.uniprot.org/core/author | "Christensen K."xsd:string |
| http://purl.uniprot.org/citations/15472150 | http://purl.uniprot.org/core/author | "Frederiksen H."xsd:string |
| http://purl.uniprot.org/citations/15472150 | http://purl.uniprot.org/core/author | "Petersen H.C."xsd:string |
| http://purl.uniprot.org/citations/15472150 | http://purl.uniprot.org/core/author | "McGue M."xsd:string |
| http://purl.uniprot.org/citations/15472150 | http://purl.uniprot.org/core/author | "Bathum L."xsd:string |
| http://purl.uniprot.org/citations/15472150 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15472150 | http://purl.uniprot.org/core/name | "J Gerontol A Biol Sci Med Sci"xsd:string |
| http://purl.uniprot.org/citations/15472150 | http://purl.uniprot.org/core/pages | "B886-9"xsd:string |
| http://purl.uniprot.org/citations/15472150 | http://purl.uniprot.org/core/title | "The catalase -262C/T promoter polymorphism and aging phenotypes."xsd:string |
| http://purl.uniprot.org/citations/15472150 | http://purl.uniprot.org/core/volume | "59"xsd:string |
| http://purl.uniprot.org/citations/15472150 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15472150 |
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