| http://purl.uniprot.org/citations/15473258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15473258 | http://www.w3.org/2000/01/rdf-schema#comment | "The homeostasis of intracellular cholesterol in animal cells is highly regulated by a complex system in which the microsomal rate-limiting enzyme 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase plays a key role in cholesterol synthesis. Substantial evidence has demonstrated that the cytosolic antioxidant enzyme CuZn superoxide dismutase (SOD1) inhibits the HMG-CoA reductase activity in rat hepatocytes and in human fibroblasts by decreasing cholesterol synthesis. Although these data suggest that SOD1 exerts a physiological role in cholesterol metabolism, it is still unclear whether the decrease of HMG-CoA reductase activity is mediated by transcriptional or by posttranscriptional events. The results of the present study, obtained by one-step RT-PCR assay, demonstrated that both SOD1 and the metal-free form of enzyme (Apo SOD1) inhibit HMG-CoA reductase gene expression in hepatocarcinoma HepG2 cells, in normal human fibroblasts, and in fibroblasts of subjects affected by familiar hypercholesterolemia. Accordingly, SOD1 could be used as a potential agent in the treatment of hypercholesterolemia, even in subjects lacking a functional LDL receptor pathway."xsd:string |
| http://purl.uniprot.org/citations/15473258 | http://purl.org/dc/terms/identifier | "doi:10.3727/000000004783992198"xsd:string |
| http://purl.uniprot.org/citations/15473258 | http://purl.uniprot.org/core/author | "Matrone G."xsd:string |
| http://purl.uniprot.org/citations/15473258 | http://purl.uniprot.org/core/author | "Mondola P."xsd:string |
| http://purl.uniprot.org/citations/15473258 | http://purl.uniprot.org/core/author | "Santillo M."xsd:string |
| http://purl.uniprot.org/citations/15473258 | http://purl.uniprot.org/core/author | "De Felice B."xsd:string |
| http://purl.uniprot.org/citations/15473258 | http://purl.uniprot.org/core/author | "Wilson R.R."xsd:string |
| http://purl.uniprot.org/citations/15473258 | http://purl.uniprot.org/core/author | "Damiano S."xsd:string |
| http://purl.uniprot.org/citations/15473258 | http://purl.uniprot.org/core/author | "Seru R."xsd:string |
| http://purl.uniprot.org/citations/15473258 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15473258 | http://purl.uniprot.org/core/name | "Gene Expr"xsd:string |
| http://purl.uniprot.org/citations/15473258 | http://purl.uniprot.org/core/pages | "29-38"xsd:string |
| http://purl.uniprot.org/citations/15473258 | http://purl.uniprot.org/core/title | "Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase gene expression by CuZn superoxide dismutase in human fibroblasts and HepG2 cells."xsd:string |
| http://purl.uniprot.org/citations/15473258 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/15473258 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15473258 |
| http://purl.uniprot.org/citations/15473258 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15473258 |
| http://purl.uniprot.org/uniprot/P00441#attribution-12EAC60BB0065EF197EBAF1FD9976536 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15473258 |
| http://purl.uniprot.org/uniprot/#_A1YYW4-mappedCitation-15473258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15473258 |
| http://purl.uniprot.org/uniprot/#_B2R649-mappedCitation-15473258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15473258 |
| http://purl.uniprot.org/uniprot/#_A8KA27-mappedCitation-15473258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15473258 |
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| http://purl.uniprot.org/uniprot/#_P00441-mappedCitation-15473258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15473258 |
| http://purl.uniprot.org/uniprot/#_L8E9E6-mappedCitation-15473258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15473258 |
| http://purl.uniprot.org/uniprot/#_P04035-mappedCitation-15473258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15473258 |