| http://purl.uniprot.org/citations/1547348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1547348 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1547348 | http://www.w3.org/2000/01/rdf-schema#comment | "Human red blood cells (RBCs) that are deficient in an integral membrane-associated protein ("stomatin") of apparent molecular mass 31 Kd show a catastrophic increase in passive membrane permeability to the univalent cations Na+ and K+ and are stomatocytic in shape. We have purified this protein from normal RBC membranes and isolated a cDNA clone coding for it. The deduced protein sequence is unrelated to that of any known ion-transport-related protein. Selective solubilization studies using detergents show that while the protein is strongly associated with the phospholipid bilayer, it also binds to the cytoskeleton. The predicted polypeptide has a single trans-membranous hydrophobic segment near the N-terminus, which would locate it in the membrane; the large C-terminal domain is hydrophilic and cytoplasmic in orientation and is presumed to be responsible for the attachment to the cytoskeleton. By inference, the protein has the function of closing a latent ion channel. The messenger RNA encoding this protein is ubiquitously distributed in different human cell types and tissues and is thus presumably a widely distributed regulator of transmembrane cation fluxes. As a membrane-bound inhibitor protein of Na+ and K+ transport, it is unique among the known components of membrane-transport proteins."xsd:string |
| http://purl.uniprot.org/citations/1547348 | http://purl.uniprot.org/core/author | "Keen J.N."xsd:string |
| http://purl.uniprot.org/citations/1547348 | http://purl.uniprot.org/core/author | "Keen J.N."xsd:string |
| http://purl.uniprot.org/citations/1547348 | http://purl.uniprot.org/core/author | "Stewart G.W."xsd:string |
| http://purl.uniprot.org/citations/1547348 | http://purl.uniprot.org/core/author | "Stewart G.W."xsd:string |
| http://purl.uniprot.org/citations/1547348 | http://purl.uniprot.org/core/author | "Argent A.C."xsd:string |
| http://purl.uniprot.org/citations/1547348 | http://purl.uniprot.org/core/author | "Argent A.C."xsd:string |
| http://purl.uniprot.org/citations/1547348 | http://purl.uniprot.org/core/author | "Casimir C.M."xsd:string |
| http://purl.uniprot.org/citations/1547348 | http://purl.uniprot.org/core/author | "Casimir C.M."xsd:string |
| http://purl.uniprot.org/citations/1547348 | http://purl.uniprot.org/core/author | "Dash B.C.J."xsd:string |
| http://purl.uniprot.org/citations/1547348 | http://purl.uniprot.org/core/author | "Dash B.C.J."xsd:string |
| http://purl.uniprot.org/citations/1547348 | http://purl.uniprot.org/core/author | "Hepworth-Jones B.E."xsd:string |
| http://purl.uniprot.org/citations/1547348 | http://purl.uniprot.org/core/author | "Hepworth-Jones B.E."xsd:string |
| http://purl.uniprot.org/citations/1547348 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1547348 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1547348 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/1547348 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/1547348 | http://purl.uniprot.org/core/pages | "1593-1601"xsd:string |
| http://purl.uniprot.org/citations/1547348 | http://purl.uniprot.org/core/pages | "1593-1601"xsd:string |
| http://purl.uniprot.org/citations/1547348 | http://purl.uniprot.org/core/title | "Isolation of cDNA coding for an ubiquitous membrane protein deficient in high Na+, low K+ stomatocytic erythrocytes."xsd:string |
| http://purl.uniprot.org/citations/1547348 | http://purl.uniprot.org/core/title | "Isolation of cDNA coding for an ubiquitous membrane protein deficient in high Na+, low K+ stomatocytic erythrocytes."xsd:string |
| http://purl.uniprot.org/citations/1547348 | http://purl.uniprot.org/core/volume | "79"xsd:string |
| http://purl.uniprot.org/citations/1547348 | http://purl.uniprot.org/core/volume | "79"xsd:string |